LACTB
lactamase beta
Summary
This gene encodes a mitochondrially-localized protein that has sequence similarity to prokaryotic beta-lactamases. Many of the residues responsible for beta-lactamase activity are not conserved in this protein, suggesting it may have a different enzymatic function. Increased expression of the related mouse gene was found to be associated with obesity. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Dec 2013]
Known Variants38 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs771795019 | 15:63,414,077 | C/T | — | uncertain significance |
| rs34925488 | 15:63,414,116 | G/C | — | benign |
| rs778350908 | 15:63,414,120 | G/C | — | uncertain significance |
| rs34297800 | 15:63,414,143 | C/T | — | benign |
| rs2036978475 | 15:63,414,254 | G/C | — | uncertain significance |
| rs2141065565 | 15:63,414,255 | G/T | — | uncertain significance |
| rs2543001493 | 15:63,414,276 | C/T | — | uncertain significance |
| rs767923145 | 15:63,414,339 | C/G | — | uncertain significance |
| rs1320187078 | 15:63,414,347 | C/A | — | uncertain significance |
| rs1400065234 | 15:63,414,394 | C/G | — | uncertain significance |
| rs189796619 | 15:63,414,723 | T/C | — | — |
| rs1229053497 | 15:63,414,853 | G/A | — | uncertain significance |
| rs752950180 | 15:63,419,073 | A/T | — | uncertain significance |
| rs1368336615 | 15:63,419,104 | G/C | — | uncertain significance |
| rs2543007704 | 15:63,419,153 | C/T | — | uncertain significance |
| rs778720573 | 15:63,419,162 | T/G | — | uncertain significance |
| rs2543007818 | 15:63,419,202 | A/C | — | uncertain significance |
| rs59027041 | 15:63,419,545 | C/A | — | benign |
| rs772125791 | 15:63,419,618 | A/G | — | uncertain significance |
| rs2543008700 | 15:63,419,742 | A/C | — | uncertain significance |
| rs201235539 | 15:63,419,763 | G/A | — | uncertain significance |
| rs142381405 | 15:63,419,840 | A/G | — | uncertain significance |
| rs2543008889 | 15:63,419,857 | A/T | — | uncertain significance |
| rs186932521 | 15:63,421,743 | G/A | — | uncertain significance |
| rs1396651361 | 15:63,421,786 | A/T | — | uncertain significance |
| rs2652822 | 15:63,422,772 | T/C | intron variant | — |
| rs1472631 | 15:63,423,739 | A/G | intron variant | — |
| rs772322623 | 15:63,433,505 | G/A | — | uncertain significance |
| rs754787506 | 15:63,433,598 | C/T | — | uncertain significance |
| rs2543020814 | 15:63,433,619 | T/C | — | uncertain significance |
| rs1208693558 | 15:63,433,703 | C/T | — | uncertain significance |
| rs746733829 | 15:63,433,775 | C/T | — | uncertain significance |
| rs1463291764 | 15:63,433,787 | G/A | — | uncertain significance |
| rs771050457 | 15:63,433,798 | C/T | — | uncertain significance |
| rs61732054 | 15:63,433,800 | G/A | — | benign |
| rs1463939302 | 15:63,433,871 | A/G | — | uncertain significance |
| rs1184322607 | 15:63,433,882 | A/G | — | uncertain significance |
| rs1040866866 | 15:63,433,894 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.