LAG3
lymphocyte activating 3
Summary
Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]
Known Variants54 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs183549619 | 12:6,882,083 | C/T | — | likely benign |
| rs369567695 | 12:6,882,388 | C/G | — | uncertain significance |
| rs533786810 | 12:6,882,432 | A/G | — | uncertain significance |
| rs774677549 | 12:6,882,880 | C/A | — | uncertain significance |
| rs2542162696 | 12:6,882,883 | C/A | — | uncertain significance |
| rs760733811 | 12:6,882,891 | C/T | — | uncertain significance |
| rs764026962 | 12:6,882,898 | C/T | — | uncertain significance |
| rs1454875127 | 12:6,883,023 | G/T | — | uncertain significance |
| rs1388787906 | 12:6,883,032 | G/A | — | uncertain significance |
| rs1941873218 | 12:6,883,077 | C/T | — | uncertain significance |
| rs766065899 | 12:6,883,132 | C/G | — | uncertain significance |
| rs1364433801 | 12:6,883,159 | A/G | — | uncertain significance |
| rs150844659 | 12:6,883,618 | G/A | downstream gene variant | — |
| rs2365095 | 12:6,883,700 | C/T | downstream gene variant | — |
| rs780275933 | 12:6,883,770 | G/A | — | uncertain significance |
| rs752254125 | 12:6,883,812 | A/G | — | uncertain significance |
| rs748156134 | 12:6,883,836 | G/A | — | uncertain significance |
| rs140328190 | 12:6,883,850 | C/T | — | uncertain significance |
| rs144186640 | 12:6,883,860 | G/A | — | uncertain significance |
| rs775297183 | 12:6,883,865 | C/T | — | uncertain significance |
| rs1206912596 | 12:6,883,877 | C/G | — | uncertain significance |
| rs749445166 | 12:6,883,896 | C/G | — | uncertain significance |
| rs147749635 | 12:6,883,899 | C/T | — | uncertain significance |
| rs2542165489 | 12:6,883,909 | C/G | — | uncertain significance |
| rs200142776 | 12:6,883,913 | G/T | — | uncertain significance |
| rs150246056 | 12:6,884,024 | G/A | — | uncertain significance |
| rs1352954057 | 12:6,884,444 | G/A | — | uncertain significance |
| rs201431526 | 12:6,884,471 | G/A | — | uncertain significance |
| rs769484845 | 12:6,884,493 | G/A | — | likely benign |
| rs2542166801 | 12:6,884,498 | C/T | — | uncertain significance |
| rs748738819 | 12:6,884,501 | T/C | — | uncertain significance |
| rs201789511 | 12:6,884,505 | G/A | — | likely benign |
| rs199709735 | 12:6,884,529 | G/A | — | likely benign |
| rs755876238 | 12:6,884,541 | C/T | — | uncertain significance |
| rs2542166942 | 12:6,884,547 | A/G | — | uncertain significance |
| rs149434241 | 12:6,884,585 | A/T | — | benign |
| rs371977904 | 12:6,884,660 | A/G | — | likely benign |
| rs2542167328 | 12:6,884,687 | G/A | — | uncertain significance |
| rs201554186 | 12:6,886,484 | T/C | — | uncertain significance |
| rs2542169792 | 12:6,886,544 | G/A | — | uncertain significance |
| rs1299506989 | 12:6,886,573 | C/G | — | uncertain significance |
| rs760058290 | 12:6,886,626 | G/C | — | uncertain significance |
| rs1941924593 | 12:6,886,963 | A/C | — | uncertain significance |
| rs774849987 | 12:6,886,982 | A/G | — | likely benign |
| rs870849 | 12:6,887,020 | T/C | missense variant | — |
| rs746353473 | 12:6,887,071 | A/G | — | uncertain significance |
| rs1941929086 | 12:6,887,414 | G/A | — | uncertain significance |
| rs1453689233 | 12:6,887,431 | G/A | — | uncertain significance |
| rs139429051 | 12:6,887,446 | A/T | — | benign |
| rs753466689 | 12:6,887,479 | G/A | — | uncertain significance |
| rs1941931518 | 12:6,887,485 | G/A | — | uncertain significance |
| rs749439413 | 12:6,887,517 | A/T | — | uncertain significance |
| rs200145792 | 12:6,887,519 | C/G | — | uncertain significance |
| rs182106657 | 12:6,887,549 | A/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.