LAIR2
leukocyte associated immunoglobulin like receptor 2
Summary
The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to leukocyte-associated immunoglobulin-like receptor 1, a membrane-bound receptor that modulates innate immune response. The protein encoded by this locus is a soluble receptor that may play roles in both inhibition of collagen-induced platelet aggregation and vessel formation during placental implantation. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]
Known Variants12 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1306495904 | 19:55,014,151 | C/T | — | uncertain significance |
| rs202049649 | 19:55,014,943 | C/T | — | uncertain significance |
| rs201955061 | 19:55,019,157 | C/T | — | likely benign |
| rs549190694 | 19:55,019,183 | C/T | — | uncertain significance |
| rs2085394862 | 19:55,019,189 | C/T | — | uncertain significance |
| rs2514758428 | 19:55,019,253 | A/C | — | uncertain significance |
| rs1393453012 | 19:55,019,315 | G/A | — | uncertain significance |
| rs375602702 | 19:55,019,343 | A/G | — | uncertain significance |
| rs2277972 | 19:55,019,607 | T/A | — | — |
| rs771618990 | 19:55,020,257 | G/A | — | likely benign |
| rs2085451483 | 19:55,021,762 | G/A | — | uncertain significance |
| rs184361852 | 19:55,021,874 | C/T | 3 prime UTR variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.