LAMP3
lysosomal associated membrane protein 3
Summary
This gene encodes lysosome-associated membrane glycoprotein 3, a type 1 integral membrane protein that belongs to a family of lysosome associated membrane proteins which form part of the glycoconjugate coat present on the inside of the lysosomal membrane. It is predominantly expressed in mature dendritic cells and serves as a marker of dendritic cell maturation. The encoded protein localizes primarily to late endosomes/lysosomes and the MHC class II compartment, where it contributes to antigen processing and presentation during adaptive immune responses. The expression of this gene is inducible under hypoxic conditions via hypoxia-inducible factor 1-alpha signaling. In cancer, this gene is frequently overexpressed and is associated with tumor progression, metastasis, therapy resistance, and poor clinical prognosis in multiple malignancies including breast, cervical, and ovarian cancers. [provided by RefSeq, Feb 2026]
Known Variants36 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs113287351 | 3:182,841,929 | C/A | — | uncertain significance |
| rs929780083 | 3:182,841,952 | T/C | — | uncertain significance |
| rs763889828 | 3:182,853,604 | C/T | — | uncertain significance |
| rs150432783 | 3:182,853,622 | C/T | — | uncertain significance |
| rs748418817 | 3:182,853,646 | C/T | — | likely benign |
| rs761547141 | 3:182,853,672 | G/A | — | uncertain significance |
| rs754179119 | 3:182,858,350 | C/T | — | uncertain significance |
| rs12493050 | 3:182,865,073 | G/T | — | — |
| rs142439586 | 3:182,865,138 | G/A | intron variant | — |
| rs683395 | 3:182,869,818 | G/T | — | — |
| rs770560672 | 3:182,870,189 | C/T | — | uncertain significance |
| rs145794465 | 3:182,870,211 | G/T | — | uncertain significance |
| rs545164497 | 3:182,870,221 | C/T | — | likely benign |
| rs148986218 | 3:182,870,237 | C/T | — | uncertain significance |
| rs1576885548 | 3:182,870,242 | G/T | — | uncertain significance |
| rs115281513 | 3:182,870,243 | C/T | — | uncertain significance |
| rs151059567 | 3:182,870,248 | G/A | — | uncertain significance |
| rs1457384832 | 3:182,870,264 | T/C | — | uncertain significance |
| rs514636 | 3:182,870,436 | G/C | — | — |
| rs112754078 | 3:182,871,482 | T/G | — | uncertain significance |
| rs751299554 | 3:182,871,503 | C/T | — | uncertain significance |
| rs1209151579 | 3:182,871,583 | G/C | — | uncertain significance |
| rs774368709 | 3:182,871,685 | C/T | — | likely benign |
| rs780437358 | 3:182,871,742 | T/C | — | uncertain significance |
| rs755276071 | 3:182,871,753 | G/T | — | uncertain significance |
| rs1288533955 | 3:182,871,835 | A/C | — | uncertain significance |
| rs777618057 | 3:182,871,838 | G/A | — | uncertain significance |
| rs114774430 | 3:182,871,912 | G/A | — | uncertain significance |
| rs369097974 | 3:182,871,951 | T/C | — | likely benign |
| rs138277927 | 3:182,871,964 | C/T | — | uncertain significance |
| rs2530688794 | 3:182,872,005 | A/G | — | likely benign |
| rs1051272293 | 3:182,872,012 | T/G | — | uncertain significance |
| rs760084694 | 3:182,872,074 | A/G | — | uncertain significance |
| rs371126983 | 3:182,872,168 | C/T | — | uncertain significance |
| rs71314284 | 3:182,878,255 | C/T | intron variant | — |
| rs776197146 | 3:182,880,415 | G/A | — | likely benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.