LAT

linker for activation of T cells

Summary

The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Known Variants155 total

rsidPosition (GRCh37)AllelesClassClinVar
rs714016:28,995,757C/Gcoding sequence variant—
rs74982715816:28,996,221C/T—likely benign
rs57211207916:28,996,234G/T—benign
rs36768448516:28,996,717C/T—likely benign
rs140887089116:28,996,722T/C—uncertain significance
rs7776072116:28,996,725G/A—benign
rs18194976716:28,996,757G/T—benign
rs78009984716:28,996,765C/T—likely benign
rs196572282116:28,996,778C/T—likely benign
rs214168366416:28,996,780G/C—likely benign
rs74793887616:28,996,790A/G—uncertain significance
rs13937473616:28,996,798C/T—likely benign
rs156753048016:28,996,803T/C—uncertain significance
rs133414999016:28,996,804G/A—likely benign
rs14326972316:28,996,831A/G—likely benign
rs132086314216:28,996,845G/C—likely benign
rs76723735816:28,996,847G/T—likely benign
rs76384684416:28,997,023C/G—likely benign
rs55276683916:28,997,038C/G—likely benign
rs13869040616:28,997,041C/T—likely benign
rs5594502416:28,997,042G/A—uncertain significance
rs78111959816:28,997,052C/T—uncertain significance
rs13986499916:28,997,059T/C—likely benign
rs56414247616:28,997,069C/T—benign
rs11296411116:28,997,070G/A—likely benign
rs5619724116:28,997,075A/G—benign
rs100448320216:28,997,078C/T—likely benign
rs196573635916:28,997,165C/T—likely benign
rs196573641016:28,997,167T/C—likely benign
rs250667720716:28,997,187G/A—likely benign
rs250667723516:28,997,190C/A—likely benign
rs14191669816:28,997,191A/T—uncertain significance
rs18678331216:28,997,203C/G—uncertain significance
rs15063540416:28,997,204G/A—uncertain significance
rs124320861516:28,997,209C/T—uncertain significance
rs250667744616:28,997,219A/G—likely benign
rs4128084616:28,997,270T/C—benign
rs77979105516:28,997,450C/T—likely benign
rs36931740116:28,997,459C/T—uncertain significance
rs74770006016:28,997,467C/G—uncertain significance
rs214168477416:28,997,468C/G—uncertain significance
rs77287685516:28,997,474C/T—uncertain significance
rs250667968916:28,997,478T/A—likely benign
rs159676754316:28,997,489C/T—uncertain significance
rs196574590716:28,997,494A/T—uncertain significance
rs250667990716:28,997,499C/G—likely benign
rs250667991616:28,997,500T/C—uncertain significance
rs13916595316:28,997,502C/T—likely benign
rs196574665716:28,997,519C/T—uncertain significance
rs134263280516:28,997,525T/C—uncertain significance
rs77682955616:28,997,529C/T—likely benign
rs4129239616:28,997,537C/T—likely benign
rs196574736916:28,997,549C/G—likely benign
rs76551563616:28,997,554C/A—likely benign
rs100052828416:28,997,688A/C—likely benign
rs120269421716:28,997,697T/C—likely benign
rs250668124116:28,997,700C/G—uncertain significance
rs130669580616:28,997,704A/G—uncertain significance
rs76191637816:28,997,706A/G—likely benign
rs20025869316:28,997,712G/A—likely benign
rs250668141416:28,997,721T/G—likely benign
rs137494905516:28,997,734C/T—uncertain significance
rs14993544516:28,997,735G/A—uncertain significance
rs37328317316:28,997,738C/T—conflicting classifications of pathogenicity
rs76355452316:28,997,739G/A—likely benign
rs75690809816:28,997,749C/T—uncertain significance
rs37571315916:28,997,750G/A—uncertain significance
rs76914466016:28,997,753G/A—uncertain significance
rs97405911116:28,997,851C/G—likely benign
rs14032708616:28,997,868T/C—likely benign
rs78168855416:28,997,873C/T—uncertain significance
rs53092245016:28,997,874G/A—likely benign
rs75666759616:28,997,880C/T—likely benign
rs96640857716:28,997,887G/A—uncertain significance
rs77457842816:28,997,895G/A—uncertain significance
rs37106196916:28,997,910T/C—likely benign
rs14569885816:28,997,940G/A—likely benign
rs139681273616:28,997,958C/A—likely benign
rs250668311816:28,997,961T/G—likely benign
rs14667909716:28,997,967G/A—likely benign
rs134595390516:28,997,992G/T—uncertain significance
rs37134126516:28,997,996C/T—uncertain significance
rs113154316:28,997,997G/A—benign
rs53515669916:28,998,012C/G—uncertain significance
rs15096128516:28,998,014A/T—uncertain significance
rs250668361016:28,998,030C/G—uncertain significance
rs18345974016:28,998,051G/A—likely benign
rs53892274116:28,998,052G/A—likely benign
rs250668418216:28,998,101C/T—likely benign
rs478811516:28,998,111T/A—benign
rs13920603516:28,998,143C/T—uncertain significance
rs37029449816:28,998,144G/A—likely benign
rs37341820216:28,998,149C/T—uncertain significance
rs128857715216:28,998,157G/C—uncertain significance
rs250668459016:28,998,158C/T—uncertain significance
rs11686694816:28,998,167C/T—uncertain significance
rs250668476516:28,998,185C/A—likely benign
rs18835046516:28,998,186C/T—likely benign
rs250668480416:28,998,188C/T—uncertain significance
rs135499034616:28,998,190G/A—uncertain significance

Showing 100 of 155 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.