LATS1
large tumor suppressor kinase 1
Summary
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]
Known Variants48 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs777519756 | 6:149,982,926 | G/A | — | uncertain significance |
| rs1365265425 | 6:149,983,218 | C/T | — | uncertain significance |
| rs199594544 | 6:149,997,774 | G/A | — | uncertain significance |
| rs1408705745 | 6:149,997,831 | C/T | — | likely pathogenic |
| rs759087156 | 6:149,997,837 | T/C | — | uncertain significance |
| rs142843346 | 6:149,997,862 | G/A | — | uncertain significance |
| rs187211175 | 6:149,998,175 | T/C | intron variant | — |
| rs9393175 | 6:149,998,723 | A/G | intron variant | — |
| rs56382749 | 6:150,001,057 | G/A | — | likely benign |
| rs1781949640 | 6:150,001,128 | G/T | — | uncertain significance |
| rs1582867955 | 6:150,001,155 | C/T | — | likely pathogenic |
| rs750318192 | 6:150,001,239 | C/G | — | uncertain significance |
| rs1781963947 | 6:150,001,467 | T/C | — | uncertain significance |
| rs2483086871 | 6:150,001,575 | C/A | — | uncertain significance |
| rs1782152084 | 6:150,004,288 | T/C | — | uncertain significance |
| rs767993990 | 6:150,004,337 | G/A | — | uncertain significance |
| rs1010190590 | 6:150,004,414 | T/C | — | uncertain significance |
| rs368619379 | 6:150,004,544 | T/C | — | uncertain significance |
| rs749182673 | 6:150,004,556 | G/A | — | uncertain significance |
| rs1782167904 | 6:150,004,568 | G/C | — | uncertain significance |
| rs55874734 | 6:150,004,634 | G/A | — | likely benign |
| rs776825053 | 6:150,004,682 | T/C | — | uncertain significance |
| rs772839695 | 6:150,004,720 | C/T | — | uncertain significance |
| rs764255571 | 6:150,004,978 | C/T | — | uncertain significance |
| rs914634583 | 6:150,005,023 | G/A | — | uncertain significance |
| rs151215982 | 6:150,005,042 | C/T | — | uncertain significance |
| rs774075024 | 6:150,005,095 | G/T | — | uncertain significance |
| rs56348064 | 6:150,005,117 | G/A | — | uncertain significance |
| rs760698439 | 6:150,005,120 | T/C | — | uncertain significance |
| rs766445284 | 6:150,005,237 | T/C | — | uncertain significance |
| rs1325999073 | 6:150,005,372 | T/C | — | uncertain significance |
| rs1225601575 | 6:150,005,389 | C/A | — | uncertain significance |
| rs1045863115 | 6:150,005,399 | G/A | — | uncertain significance |
| rs373418517 | 6:150,005,473 | G/A | — | uncertain significance |
| rs1240662853 | 6:150,005,476 | G/A | — | uncertain significance |
| rs1326387583 | 6:150,005,567 | T/A | — | uncertain significance |
| rs996500103 | 6:150,005,595 | A/C | — | uncertain significance |
| rs756979117 | 6:150,005,612 | G/A | — | uncertain significance |
| rs34793526 | 6:150,005,615 | T/C | — | benign |
| rs763594987 | 6:150,005,704 | C/T | — | uncertain significance |
| rs150467898 | 6:150,014,139 | G/A | intron variant | — |
| rs2483228226 | 6:150,016,231 | T/C | — | uncertain significance |
| rs2483230018 | 6:150,016,331 | T/A | — | pathogenic |
| rs55945045 | 6:150,022,977 | G/A | — | likely benign |
| rs754711137 | 6:150,023,163 | T/C | — | uncertain significance |
| rs191160444 | 6:150,023,181 | G/C | — | uncertain significance |
| rs144413146 | 6:150,030,905 | G/A | intron variant | — |
| rs777771162 | 6:150,032,103 | C/G | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.