LBP
lipopolysaccharide binding protein
Summary
The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012]
Known Variants58 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs5741812 | 20:36,973,999 | A/C | — | — |
| rs754026422 | 20:36,974,939 | C/T | — | uncertain significance |
| rs140031031 | 20:36,975,013 | G/A | — | uncertain significance |
| rs11536940 | 20:36,977,636 | G/A | intron variant | — |
| rs1739654 | 20:36,977,970 | G/A | synonymous variant | benign |
| rs367547608 | 20:36,978,050 | G/T | — | uncertain significance |
| rs1208773082 | 20:36,978,057 | G/C | — | uncertain significance |
| rs140384988 | 20:36,979,214 | C/T | — | likely benign |
| rs200742486 | 20:36,979,215 | C/G | — | uncertain significance |
| rs45534540 | 20:36,979,245 | T/A | — | likely benign |
| rs5744203 | 20:36,979,250 | G/A | — | likely benign |
| rs753750104 | 20:36,979,312 | A/G | — | uncertain significance |
| rs1204159456 | 20:36,979,341 | T/C | — | likely benign |
| rs11536943 | 20:36,979,726 | G/A | intron variant | — |
| rs1018470 | 20:36,980,096 | T/G | intron variant | — |
| rs186516958 | 20:36,981,063 | C/T | intron variant | — |
| rs2232585 | 20:36,982,688 | C/A | — | benign |
| rs36015492 | 20:36,982,754 | G/A | missense variant | — |
| rs143797991 | 20:36,982,763 | G/A | — | uncertain significance |
| rs5744204 | 20:36,982,811 | G/A | missense variant | — |
| rs759636611 | 20:36,982,817 | G/A | — | uncertain significance |
| rs754134930 | 20:36,982,838 | G/C | — | uncertain significance |
| rs141831997 | 20:36,985,583 | C/T | intron variant | — |
| rs550076753 | 20:36,987,866 | C/T | — | — |
| rs1780623 | 20:36,989,269 | C/T | intron variant | — |
| rs2232596 | 20:36,989,381 | G/C | synonymous variant | benign |
| rs2232597 | 20:36,989,391 | G/A | — | benign |
| rs138894985 | 20:36,989,410 | A/G | — | likely benign |
| rs11536972 | 20:36,991,891 | T/C | intron variant | — |
| rs746204464 | 20:36,992,635 | C/T | — | uncertain significance |
| rs545550026 | 20:36,992,652 | G/A | — | uncertain significance |
| rs2515939650 | 20:36,992,659 | T/C | — | uncertain significance |
| rs2232601 | 20:36,992,702 | G/A | — | likely benign |
| rs73909012 | 20:36,993,231 | G/A | — | benign |
| rs768592841 | 20:36,993,254 | C/T | — | uncertain significance |
| rs769757826 | 20:36,993,261 | C/T | — | uncertain significance |
| rs1170930146 | 20:36,993,307 | C/A | — | uncertain significance |
| rs867224254 | 20:36,993,330 | C/T | — | uncertain significance |
| rs2515940569 | 20:36,993,378 | A/G | — | uncertain significance |
| rs150838547 | 20:36,995,417 | C/T | — | uncertain significance |
| rs374109956 | 20:36,995,426 | C/T | — | uncertain significance |
| rs755659532 | 20:36,995,432 | T/G | — | uncertain significance |
| rs2232613 | 20:36,997,655 | T/C | — | uncertain significance |
| rs5744212 | 20:36,997,672 | C/T | — | likely benign |
| rs375340634 | 20:36,997,762 | C/T | — | uncertain significance |
| rs5744213 | 20:36,997,795 | C/T | missense variant | — |
| rs146457097 | 20:36,999,435 | C/T | — | likely benign |
| rs2515945238 | 20:36,999,441 | G/C | — | uncertain significance |
| rs2076899957 | 20:36,999,935 | A/G | — | uncertain significance |
| rs1378756729 | 20:36,999,937 | C/G | — | uncertain significance |
| rs2515945822 | 20:36,999,963 | C/A | — | uncertain significance |
| rs2232618 | 20:37,001,761 | T/C | missense variant | — |
| rs142724815 | 20:37,001,771 | A/C | — | benign |
| rs2232620 | 20:37,002,591 | C/T | — | benign |
| rs774841468 | 20:37,002,592 | G/A | — | likely benign |
| rs374520012 | 20:37,002,638 | T/C | — | likely benign |
| rs748401837 | 20:37,002,653 | A/G | — | uncertain significance |
| rs771558622 | 20:37,005,301 | T/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.