LCP2
lymphocyte cytosolic protein 2
Summary
This gene encodes an adapter protein that acts as a substrate of the T cell antigen receptor (TCR)-activated protein tyrosine kinase pathway. The encoded protein associates with growth factor receptor bound protein 2, and is thought to play a role TCR-mediated intracellular signal transduction. A similar protein in mouse plays a role in normal T-cell development and activation. Mice lacking this gene show subcutaneous and intraperitoneal fetal hemorrhaging, dysfunctional platelets and impaired viability. [provided by RefSeq, Nov 2016]
Known Variants41 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs771198621 | 5:169,675,723 | G/A | — | uncertain significance |
| rs187889192 | 5:169,675,739 | A/G | — | likely benign |
| rs760300648 | 5:169,679,460 | G/A | — | uncertain significance |
| rs2532100864 | 5:169,679,482 | T/C | — | uncertain significance |
| rs770608317 | 5:169,680,134 | C/T | — | uncertain significance |
| rs745596318 | 5:169,680,137 | G/A | — | uncertain significance |
| rs34192428 | 5:169,680,139 | G/C | — | likely benign |
| rs202102953 | 5:169,680,146 | G/T | — | uncertain significance |
| rs539996327 | 5:169,680,189 | G/A | — | likely benign |
| rs368601383 | 5:169,685,128 | C/T | — | uncertain significance |
| rs766913071 | 5:169,685,158 | G/A | — | uncertain significance |
| rs315717 | 5:169,685,163 | C/T | — | benign |
| rs432621 | 5:169,686,007 | T/C | — | benign |
| rs2113164095 | 5:169,688,110 | C/T | — | pathogenic |
| rs200367246 | 5:169,688,140 | G/T | — | uncertain significance |
| rs2338871 | 5:169,689,519 | A/G | — | benign |
| rs395407 | 5:169,689,604 | C/G | — | benign |
| rs2532114108 | 5:169,689,651 | G/C | — | uncertain significance |
| rs377124973 | 5:169,689,669 | G/A | — | uncertain significance |
| rs202014238 | 5:169,689,711 | G/A | — | uncertain significance |
| rs374441441 | 5:169,689,984 | G/C | — | uncertain significance |
| rs376708785 | 5:169,693,860 | G/A | — | uncertain significance |
| rs200231689 | 5:169,694,057 | T/C | — | uncertain significance |
| rs368344059 | 5:169,695,400 | G/A | — | uncertain significance |
| rs763246906 | 5:169,695,404 | G/A | — | likely benign |
| rs535050789 | 5:169,695,412 | G/T | — | uncertain significance |
| rs779018199 | 5:169,695,441 | G/C | — | uncertain significance |
| rs2292254 | 5:169,695,446 | C/T | — | benign |
| rs315745 | 5:169,697,707 | G/A | — | benign |
| rs375649336 | 5:169,697,818 | G/A | — | uncertain significance |
| rs369823137 | 5:169,697,831 | C/T | — | uncertain significance |
| rs752170242 | 5:169,697,903 | T/G | — | uncertain significance |
| rs1761887520 | 5:169,697,912 | C/T | — | uncertain significance |
| rs315744 | 5:169,698,028 | A/G | — | benign |
| rs371600845 | 5:169,702,344 | G/A | — | uncertain significance |
| rs2271146 | 5:169,702,390 | A/C | — | benign |
| rs200125818 | 5:169,714,981 | G/A | — | uncertain significance |
| rs2532148012 | 5:169,715,013 | G/A | — | uncertain significance |
| rs315721 | 5:169,715,038 | A/G | intron variant | benign |
| rs960180385 | 5:169,724,564 | C/T | — | uncertain significance |
| rs765109612 | 5:169,724,570 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.