LECT2
leukocyte cell derived chemotaxin 2
Summary
This gene encodes a secreted, 16 kDa protein that acts as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. This protein has high sequence similarity to the chondromodulin repeat regions of the chicken myb-induced myeloid 1 protein. A polymorphism in this gene may be associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008]
Known Variants13 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs31529 | 5:135,282,832 | T/C | — | — |
| rs944660715 | 5:135,283,027 | T/C | — | uncertain significance |
| rs755344880 | 5:135,283,044 | C/T | — | likely benign |
| rs185417453 | 5:135,283,385 | G/A | intron variant | — |
| rs368558732 | 5:135,286,954 | T/C | — | uncertain significance |
| rs31517 | 5:135,287,029 | T/C | — | benign |
| rs549258032 | 5:135,288,611 | T/C | — | uncertain significance |
| rs62623707 | 5:135,288,632 | A/G | missense variant | — |
| rs1482759550 | 5:135,288,633 | T/C | — | uncertain significance |
| rs201289201 | 5:135,288,647 | C/T | — | uncertain significance |
| rs147570962 | 5:135,288,864 | G/T | downstream gene variant | — |
| rs146096717 | 5:135,289,219 | A/G | downstream gene variant | — |
| rs191708170 | 5:135,291,333 | G/C | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.