LIMCH1

LIM and calponin homology domains 1

Summary

Enables myosin II head/neck binding activity. Involved in several processes, including cytoplasmic actin-based contraction involved in cell motility; positive regulation of stress fiber assembly; and regulation of focal adhesion assembly. Located in myosin II complex and stress fiber. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants81 total

rsidPosition (GRCh37)AllelesClassClinVar
rs13433498114:41,362,910C/Auncertain significance
rs12140397354:41,362,916C/Guncertain significance
rs43496334:41,485,212G/T
rs5502629154:41,489,858A/G
rs12039631304:41,496,569G/Auncertain significance
rs15540725574:41,496,610A/Guncertain significance
rs1410756834:41,601,021A/Guncertain significance
rs25518450704:41,605,900A/Tuncertain significance
rs7564166544:41,607,971A/Guncertain significance
rs1468383504:41,607,998G/Auncertain significance
rs25518675714:41,615,630T/Guncertain significance
rs5317823274:41,615,633C/Tuncertain significance
rs25518676144:41,615,639A/Cuncertain significance
rs25518861284:41,621,289C/Guncertain significance
rs1474085404:41,621,367C/Tmissense variantuncertain significance
rs7698275694:41,621,406G/Tuncertain significance
rs7662542134:41,621,423G/Auncertain significance
rs1879425634:41,634,826G/Alikely benign
rs43452204:41,639,516A/T
rs7783729804:41,646,527A/Guncertain significance
rs8686970314:41,646,558C/Tuncertain significance
rs5421340974:41,648,150G/Auncertain significance
rs1406895824:41,648,507G/Auncertain significance
rs7716477314:41,648,545C/Tuncertain significance
rs20940694444:41,648,554G/Cuncertain significance
rs7544534324:41,648,561C/Tuncertain significance
rs7778855094:41,648,599A/Guncertain significance
rs7490186214:41,648,621G/Tuncertain significance
rs3733418504:41,648,654A/Guncertain significance
rs1437330864:41,648,713C/Tuncertain significance
rs7676721934:41,648,714G/Auncertain significance
rs1481339564:41,648,767G/Alikely benign
rs7635150084:41,648,773G/Alikely benign
rs25519613354:41,648,823A/Tuncertain significance
rs1386896214:41,648,825C/Tuncertain significance
rs7691758514:41,648,858C/Tuncertain significance
rs2006206124:41,648,862G/Cuncertain significance
rs1996021504:41,648,894T/Guncertain significance
rs20940847154:41,648,902A/Guncertain significance
rs7516023764:41,652,416G/Auncertain significance
rs2010897744:41,652,426G/Cuncertain significance
rs5628120914:41,652,441C/Tuncertain significance
rs14222738054:41,652,494C/Tuncertain significance
rs1478748164:41,652,521G/Auncertain significance
rs2018257154:41,652,522A/Guncertain significance
rs7602822704:41,652,525G/Cuncertain significance
rs9066443264:41,652,609T/Cuncertain significance
rs1439878354:41,652,622C/Tlikely benign
rs7518804534:41,663,443A/Cuncertain significance
rs10268539174:41,663,467C/Guncertain significance
rs7802773464:41,663,471A/Guncertain significance
rs1397386874:41,663,489G/Alikely benign
rs575478854:41,663,518G/Auncertain significance
rs1841177214:41,664,841C/Tuncertain significance
rs2003517034:41,664,868G/Auncertain significance
rs7595823564:41,664,875C/Auncertain significance
rs5380257344:41,664,894G/Auncertain significance
rs10017932034:41,664,941A/Cuncertain significance
rs20946805314:41,664,988T/Cuncertain significance
rs12440186484:41,664,991T/Cuncertain significance
rs7617543204:41,668,606A/Guncertain significance
rs1385671754:41,668,624C/Tuncertain significance
rs1492922654:41,668,651A/Guncertain significance
rs1459256864:41,678,433G/Auncertain significance
rs3743303464:41,678,468C/Tuncertain significance
rs25520792984:41,682,042A/Cuncertain significance
rs17144151724:41,682,069A/Guncertain significance
rs7572041554:41,682,111A/Guncertain significance
rs1999806564:41,683,026G/Auncertain significance
rs7474386654:41,684,385A/Cuncertain significance
rs10462882624:41,686,468T/Guncertain significance
rs7722819594:41,686,475C/Tuncertain significance
rs617459634:41,686,520C/Tlikely benign
rs25520847444:41,687,755T/Auncertain significance
rs1491156244:41,687,764C/Auncertain significance
rs7718354274:41,687,807A/Guncertain significance
rs9414976094:41,687,825G/Auncertain significance
rs3703365294:41,687,844G/Auncertain significance
rs3690482874:41,689,868G/Tuncertain significance
rs1403416434:41,689,913C/Guncertain significance
rs7807644644:41,691,599G/Auncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.