LPO
lactoperoxidase
Summary
This gene encodes a member of the peroxidase family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Following its secretion from salivary, mammary, and other mucosal glands, this enzyme catalyzes the generation of the antimicrobial substance hypothiocyanous acid. This gene is present in a gene cluster on chromosome 17. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
Known Variants45 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs564859473 | 17:56,314,779 | C/A | — | — |
| rs8178291 | 17:56,320,370 | C/G | — | benign |
| rs200716527 | 17:56,321,436 | G/A | — | uncertain significance |
| rs8178297 | 17:56,321,451 | G/C | — | benign |
| rs140740050 | 17:56,324,913 | G/A | — | uncertain significance |
| rs757344771 | 17:56,324,918 | C/T | — | uncertain significance |
| rs8178318 | 17:56,324,988 | C/T | — | benign |
| rs1969906065 | 17:56,326,463 | G/A | — | uncertain significance |
| rs149218134 | 17:56,326,477 | C/G | — | uncertain significance |
| rs773510542 | 17:56,326,531 | A/C | — | uncertain significance |
| rs772131545 | 17:56,327,031 | C/A | — | uncertain significance |
| rs775584287 | 17:56,327,040 | G/A | — | uncertain significance |
| rs756019710 | 17:56,327,894 | C/T | — | uncertain significance |
| rs372324686 | 17:56,327,975 | C/T | — | uncertain significance |
| rs8178340 | 17:56,328,251 | T/A | regulatory region variant | — |
| rs778807820 | 17:56,329,580 | A/C | — | uncertain significance |
| rs139781655 | 17:56,329,652 | T/A | — | uncertain significance |
| rs763969451 | 17:56,329,699 | G/A | — | uncertain significance |
| rs142897237 | 17:56,329,794 | G/T | — | benign |
| rs202110302 | 17:56,329,799 | A/G | — | uncertain significance |
| rs751513712 | 17:56,329,813 | C/T | — | uncertain significance |
| rs148204062 | 17:56,332,188 | A/C | — | benign |
| rs2509498711 | 17:56,332,196 | T/C | — | uncertain significance |
| rs1458420390 | 17:56,332,239 | C/A | — | uncertain significance |
| rs758467533 | 17:56,332,267 | A/C | — | uncertain significance |
| rs531238609 | 17:56,332,306 | C/T | — | uncertain significance |
| rs546552332 | 17:56,339,594 | A/C | — | — |
| rs8178395 | 17:56,341,733 | C/G | — | — |
| rs773139287 | 17:56,342,234 | C/A | — | uncertain significance |
| rs2509508067 | 17:56,342,306 | T/C | — | uncertain significance |
| rs751147632 | 17:56,342,315 | C/G | — | uncertain significance |
| rs144914036 | 17:56,343,598 | G/A | — | uncertain significance |
| rs755817948 | 17:56,343,624 | A/G | — | uncertain significance |
| rs780043527 | 17:56,343,670 | G/A | — | uncertain significance |
| rs8178406 | 17:56,344,443 | T/A | — | — |
| rs145168535 | 17:56,344,749 | C/T | — | uncertain significance |
| rs745968529 | 17:56,344,884 | G/A | — | uncertain significance |
| rs8178410 | 17:56,344,957 | T/C | — | benign |
| rs2509512473 | 17:56,345,163 | C/A | — | uncertain significance |
| rs2509512536 | 17:56,345,191 | G/T | — | uncertain significance |
| rs372270079 | 17:56,345,192 | A/G | — | uncertain significance |
| rs1240684439 | 17:56,345,197 | C/G | — | uncertain significance |
| rs987949946 | 17:56,345,201 | A/T | — | uncertain significance |
| rs1385919434 | 17:56,345,219 | G/A | — | uncertain significance |
| rs761211333 | 17:56,345,296 | G/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.