LRRC2
leucine rich repeat containing 2
Summary
This gene encodes a member of the leucine-rich repeat-containing family of proteins, which function in diverse biological pathways. This family member may possibly be a nuclear protein. Similarity to the RAS suppressor protein, as well as expression down-regulation observed in tumor cells, suggests that it may function as a tumor suppressor. The gene is located in the chromosome 3 common eliminated region 1 (C3CER1), a 1.4 Mb region that is commonly deleted in diverse tumors. A related pseudogene has been identified on chromosome 2. [provided by RefSeq, Sep 2011]
Known Variants28 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs11720094 | 3:46,559,911 | G/T | — | — |
| rs2528704602 | 3:46,560,526 | A/G | — | uncertain significance |
| rs148260840 | 3:46,563,013 | T/A | — | uncertain significance |
| rs769382026 | 3:46,563,032 | A/G | — | uncertain significance |
| rs201560633 | 3:46,563,048 | C/T | — | uncertain significance |
| rs746621733 | 3:46,563,068 | C/T | — | uncertain significance |
| rs141371381 | 3:46,563,069 | G/A | — | benign |
| rs150762901 | 3:46,563,125 | G/A | — | benign |
| rs114127275 | 3:46,566,731 | A/C | — | — |
| rs1373188214 | 3:46,568,922 | G/T | — | uncertain significance |
| rs1474812597 | 3:46,568,926 | T/G | — | uncertain significance |
| rs769664566 | 3:46,569,008 | C/T | — | uncertain significance |
| rs2528722229 | 3:46,571,401 | A/G | — | uncertain significance |
| rs753497746 | 3:46,571,410 | G/A | — | uncertain significance |
| rs2528727677 | 3:46,574,354 | A/G | — | uncertain significance |
| rs115132856 | 3:46,574,357 | T/G | — | benign |
| rs185219095 | 3:46,578,100 | A/G | intron variant | — |
| rs1048870621 | 3:46,580,553 | G/A | — | uncertain significance |
| rs2528738838 | 3:46,580,633 | G/A | — | uncertain significance |
| rs34850909 | 3:46,580,676 | A/T | — | benign |
| rs187504805 | 3:46,581,297 | G/A | regulatory region variant | — |
| rs770693154 | 3:46,586,547 | C/G | — | uncertain significance |
| rs750947485 | 3:46,586,580 | G/A | — | uncertain significance |
| rs754576880 | 3:46,586,612 | C/G | — | uncertain significance |
| rs146246618 | 3:46,586,648 | C/T | — | uncertain significance |
| rs773740182 | 3:46,586,674 | C/A | — | uncertain significance |
| rs142071651 | 3:46,592,967 | C/T | — | uncertain significance |
| rs201529548 | 3:46,593,068 | A/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.