LRTOMT

leucine rich transmembrane and O-methyltransferase domain containing

Summary

This locus represents naturally occurring readthrough transcription between the neighboring LRRC51 (leucine-rich repeat containing 51) and TOMT (transmembrane O-methyltransferase) genes on chromosome 11. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product. Multiple reports implicate mutations in this gene in nonsyndromic deafness.[provided by RefSeq, Feb 2021]

Known Variants177 total

rsidPosition (GRCh37)AllelesClassClinVar
rs11603832411:71,791,368C/T—uncertain significance
rs53500377611:71,791,437C/T—uncertain significance
rs18583010711:71,791,491C/A—uncertain significance
rs194407691811:71,791,492C/T—uncertain significance
rs11491292511:71,791,510G/A—likely benign
rs99046230211:71,791,528T/G—uncertain significance
rs88604862111:71,791,548A/G—uncertain significance
rs91845467411:71,791,550C/G—uncertain significance
rs11153754411:71,791,651G/A—conflicting classifications of pathogenicity
rs88604862211:71,791,699G/A—uncertain significance
rs19030764611:71,791,727T/A—uncertain significance
rs88604862311:71,791,772G/T—uncertain significance
rs145042617911:71,791,800A/G—uncertain significance
rs104206859911:71,791,831T/C—uncertain significance
rs88604862411:71,791,844G/A—uncertain significance
rs88604862511:71,791,874T/C—uncertain significance
rs88604862611:71,791,909G/A—uncertain significance
rs76796136811:71,791,936G/A—uncertain significance
rs67347811:71,799,104G/A—benign
rs11607821211:71,799,602C/T—likely benign
rs67080211:71,799,668A/C—benign
rs15032541911:71,799,880A/G—likely benign
rs7879658511:71,799,965T/C—benign
rs14694281511:71,800,166G/A—likely benign
rs11440007111:71,804,433A/G—likely benign
rs225086611:71,804,513G/A—benign
rs88604862711:71,804,558G/A—uncertain significance
rs78029962111:71,804,574C/T—conflicting classifications of pathogenicity
rs54588552311:71,804,575G/A—uncertain significance
rs13955409511:71,804,607C/G—uncertain significance
rs14413903811:71,804,609G/T—uncertain significance
rs138261404211:71,804,689A/G—uncertain significance
rs15101648211:71,804,712G/A—benign
rs36910515511:71,804,740T/C—uncertain significance
rs56127608711:71,804,766G/C—benign
rs53564255111:71,806,020T/C—uncertain significance
rs14548805311:71,806,052G/A—uncertain significance
rs37186894111:71,806,150C/T—likely benign
rs19991632011:71,806,160G/A—likely benign
rs14710696111:71,806,451G/A—likely benign
rs113169169411:71,806,489G/A—uncertain significance
rs15024548811:71,806,515A/G—likely benign
rs56334339611:71,806,529A/C—likely benign
rs14206158511:71,806,588C/T—likely benign
rs19950820711:71,806,603A/G—likely benign
rs7960166311:71,807,826C/T—likely benign
rs1788488311:71,808,056C/T—benign
rs8008926711:71,815,966T/C—benign
rs249940947111:71,815,994G/C—likely benign
rs75790981811:71,816,005C/T—likely benign
rs78168234611:71,816,006G/A—likely benign
rs87665786511:71,816,028A/C—uncertain significance
rs194561031311:71,816,030C/A—uncertain significance
rs56237219511:71,816,036T/C—uncertain significance
rs1227208611:71,816,044G/C—likely benign
rs146136595811:71,816,053G/C—uncertain significance
rs1229388511:71,816,092T/A—benign
rs1227221311:71,816,219G/A—benign
rs11489544811:71,816,766G/C—likely benign
rs213518594011:71,816,964T/C—likely benign
rs87665750011:71,817,015A/G—likely benign
rs87665750111:71,817,016T/C—likely benign
rs137239980511:71,817,052C/T—conflicting classifications of pathogenicity
rs95005795911:71,817,053G/A—uncertain significance
rs37645963211:71,817,058C/T—uncertain significance
rs76426835011:71,817,059G/A—uncertain significance
rs72750315211:71,817,063C/G—uncertain significance
rs129880414811:71,817,070C/T—likely pathogenic
rs104474942111:71,817,071G/A—uncertain significance
rs253891117911:71,817,077T/C—uncertain significance
rs57077492511:71,817,082C/T—likely benign
rs87665750211:71,817,086C/T—conflicting classifications of pathogenicity
rs55609301011:71,817,087G/A—uncertain significance
rs57463176511:71,817,089T/G—uncertain significance
rs87665786411:71,817,094C/G—uncertain significance
rs78046829211:71,817,097C/T—pathogenic
rs121215017611:71,817,098G/A—uncertain significance
rs89000972211:71,817,102C/T—likely benign
rs18871512911:71,817,107G/A—conflicting classifications of pathogenicity
rs39751662611:71,817,120A/G—conflicting classifications of pathogenicity
rs74769577511:71,817,128G/A—uncertain significance
rs74698107411:71,817,147C/G—uncertain significance
rs77056655711:71,817,154G/A—uncertain significance
rs95785704411:71,817,164A/G—uncertain significance
rs123907483611:71,817,166G/C—uncertain significance
rs88604862911:71,817,174C/T—uncertain significance
rs99986310711:71,817,221G/A—conflicting classifications of pathogenicity
rs77454484411:71,817,225C/T—conflicting classifications of pathogenicity
rs76771389911:71,817,238C/T—uncertain significance
rs140553052311:71,817,242T/C—uncertain significance
rs18109271311:71,817,250G/A—conflicting classifications of pathogenicity
rs156533006611:71,817,257G/A—pathogenic
rs56439096711:71,817,282C/T—likely benign
rs1716197611:71,818,918G/A—benign
rs76212876211:71,818,983C/T—uncertain significance
rs57257051311:71,818,984G/A—uncertain significance
rs20014946111:71,818,990T/C—uncertain significance
rs7665747411:71,819,007G/C—conflicting classifications of pathogenicity
rs137220777911:71,819,009T/G—likely benign
rs133846923411:71,819,064G/A—uncertain significance

Showing 100 of 177 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.