LRTOMT

leucine rich transmembrane and O-methyltransferase domain containing

Summary

This locus represents naturally occurring readthrough transcription between the neighboring LRRC51 (leucine-rich repeat containing 51) and TOMT (transmembrane O-methyltransferase) genes on chromosome 11. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product. Multiple reports implicate mutations in this gene in nonsyndromic deafness.[provided by RefSeq, Feb 2021]

Known Variants177 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs116038324	11:71,791,368	C/T	—	uncertain significance
rs535003776	11:71,791,437	C/T	—	uncertain significance
rs185830107	11:71,791,491	C/A	—	uncertain significance
rs1944076918	11:71,791,492	C/T	—	uncertain significance
rs114912925	11:71,791,510	G/A	—	likely benign
rs990462302	11:71,791,528	T/G	—	uncertain significance
rs886048621	11:71,791,548	A/G	—	uncertain significance
rs918454674	11:71,791,550	C/G	—	uncertain significance
rs111537544	11:71,791,651	G/A	—	conflicting classifications of pathogenicity
rs886048622	11:71,791,699	G/A	—	uncertain significance
rs190307646	11:71,791,727	T/A	—	uncertain significance
rs886048623	11:71,791,772	G/T	—	uncertain significance
rs1450426179	11:71,791,800	A/G	—	uncertain significance
rs1042068599	11:71,791,831	T/C	—	uncertain significance
rs886048624	11:71,791,844	G/A	—	uncertain significance
rs886048625	11:71,791,874	T/C	—	uncertain significance
rs886048626	11:71,791,909	G/A	—	uncertain significance
rs767961368	11:71,791,936	G/A	—	uncertain significance
rs673478	11:71,799,104	G/A	—	benign
rs116078212	11:71,799,602	C/T	—	likely benign
rs670802	11:71,799,668	A/C	—	benign
rs150325419	11:71,799,880	A/G	—	likely benign
rs78796585	11:71,799,965	T/C	—	benign
rs146942815	11:71,800,166	G/A	—	likely benign
rs114400071	11:71,804,433	A/G	—	likely benign
rs2250866	11:71,804,513	G/A	—	benign
rs886048627	11:71,804,558	G/A	—	uncertain significance
rs780299621	11:71,804,574	C/T	—	conflicting classifications of pathogenicity
rs545885523	11:71,804,575	G/A	—	uncertain significance
rs139554095	11:71,804,607	C/G	—	uncertain significance
rs144139038	11:71,804,609	G/T	—	uncertain significance
rs1382614042	11:71,804,689	A/G	—	uncertain significance
rs151016482	11:71,804,712	G/A	—	benign
rs369105155	11:71,804,740	T/C	—	uncertain significance
rs561276087	11:71,804,766	G/C	—	benign
rs535642551	11:71,806,020	T/C	—	uncertain significance
rs145488053	11:71,806,052	G/A	—	uncertain significance
rs371868941	11:71,806,150	C/T	—	likely benign
rs199916320	11:71,806,160	G/A	—	likely benign
rs147106961	11:71,806,451	G/A	—	likely benign
rs1131691694	11:71,806,489	G/A	—	uncertain significance
rs150245488	11:71,806,515	A/G	—	likely benign
rs563343396	11:71,806,529	A/C	—	likely benign
rs142061585	11:71,806,588	C/T	—	likely benign
rs199508207	11:71,806,603	A/G	—	likely benign
rs79601663	11:71,807,826	C/T	—	likely benign
rs17884883	11:71,808,056	C/T	—	benign
rs80089267	11:71,815,966	T/C	—	benign
rs2499409471	11:71,815,994	G/C	—	likely benign
rs757909818	11:71,816,005	C/T	—	likely benign
rs781682346	11:71,816,006	G/A	—	likely benign
rs876657865	11:71,816,028	A/C	—	uncertain significance
rs1945610313	11:71,816,030	C/A	—	uncertain significance
rs562372195	11:71,816,036	T/C	—	uncertain significance
rs12272086	11:71,816,044	G/C	—	likely benign
rs1461365958	11:71,816,053	G/C	—	uncertain significance
rs12293885	11:71,816,092	T/A	—	benign
rs12272213	11:71,816,219	G/A	—	benign
rs114895448	11:71,816,766	G/C	—	likely benign
rs2135185940	11:71,816,964	T/C	—	likely benign
rs876657500	11:71,817,015	A/G	—	likely benign
rs876657501	11:71,817,016	T/C	—	likely benign
rs1372399805	11:71,817,052	C/T	—	conflicting classifications of pathogenicity
rs950057959	11:71,817,053	G/A	—	uncertain significance
rs376459632	11:71,817,058	C/T	—	uncertain significance
rs764268350	11:71,817,059	G/A	—	uncertain significance
rs727503152	11:71,817,063	C/G	—	uncertain significance
rs1298804148	11:71,817,070	C/T	—	likely pathogenic
rs1044749421	11:71,817,071	G/A	—	uncertain significance
rs2538911179	11:71,817,077	T/C	—	uncertain significance
rs570774925	11:71,817,082	C/T	—	likely benign
rs876657502	11:71,817,086	C/T	—	conflicting classifications of pathogenicity
rs556093010	11:71,817,087	G/A	—	uncertain significance
rs574631765	11:71,817,089	T/G	—	uncertain significance
rs876657864	11:71,817,094	C/G	—	uncertain significance
rs780468292	11:71,817,097	C/T	—	pathogenic
rs1212150176	11:71,817,098	G/A	—	uncertain significance
rs890009722	11:71,817,102	C/T	—	likely benign
rs188715129	11:71,817,107	G/A	—	conflicting classifications of pathogenicity
rs397516626	11:71,817,120	A/G	—	conflicting classifications of pathogenicity
rs747695775	11:71,817,128	G/A	—	uncertain significance
rs746981074	11:71,817,147	C/G	—	uncertain significance
rs770566557	11:71,817,154	G/A	—	uncertain significance
rs957857044	11:71,817,164	A/G	—	uncertain significance
rs1239074836	11:71,817,166	G/C	—	uncertain significance
rs886048629	11:71,817,174	C/T	—	uncertain significance
rs999863107	11:71,817,221	G/A	—	conflicting classifications of pathogenicity
rs774544844	11:71,817,225	C/T	—	conflicting classifications of pathogenicity
rs767713899	11:71,817,238	C/T	—	uncertain significance
rs1405530523	11:71,817,242	T/C	—	uncertain significance
rs181092713	11:71,817,250	G/A	—	conflicting classifications of pathogenicity
rs1565330066	11:71,817,257	G/A	—	pathogenic
rs564390967	11:71,817,282	C/T	—	likely benign
rs17161976	11:71,818,918	G/A	—	benign
rs762128762	11:71,818,983	C/T	—	uncertain significance
rs572570513	11:71,818,984	G/A	—	uncertain significance
rs200149461	11:71,818,990	T/C	—	uncertain significance
rs76657474	11:71,819,007	G/C	—	conflicting classifications of pathogenicity
rs1372207779	11:71,819,009	T/G	—	likely benign
rs1338469234	11:71,819,064	G/A	—	uncertain significance

Showing 100 of 177 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.