LXN
latexin
Summary
This gene encodes the only known protein inhibitor of zinc-dependent metallocarboxypeptidases. The encoded protein, latexin, downregulates the population size of hematopoietic stem cells. This protein is found to be downregulated in cancer cells because of promoter hypermethylation. [provided by RefSeq, Jul 2020]
Known Variants11 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs863224035 | 3:158,384,157 | C/T | missense variant | pathogenic |
| rs761095873 | 3:158,384,170 | — | — | pathogenic |
| rs745485339 | 3:158,384,800 | C/G | — | uncertain significance |
| rs150659006 | 3:158,384,811 | A/G | — | uncertain significance |
| rs149695048 | 3:158,386,791 | C/T | — | benign |
| rs147759114 | 3:158,386,886 | C/T | — | benign |
| rs2472989238 | 3:158,386,901 | G/C | — | uncertain significance |
| rs184291369 | 3:158,389,957 | G/A | regulatory region variant | — |
| rs371457216 | 3:158,390,188 | G/A | — | uncertain significance |
| rs917308119 | 3:158,390,216 | G/C | — | likely benign |
| rs116224250 | 3:158,390,230 | G/A | — | benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.