LYNX1
Ly6/neurotoxin 1
Summary
This gene encodes a GPI-anchored, cell membrane bound member of the Ly6/uPAR (LU) superfamily of proteins containing the unique three-finger LU domain. This protein interacts with nicotinic acetylcholine receptors (nAChRs), and is thought to function as a modulator of nAChR activity to prevent excessive excitation. Alternatively spliced transcript variants have been found for this gene. Read-through transcription between this gene and the neighboring downstream gene (SLURP2) generates naturally-occurring transcripts (LYNX1-SLURP2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Sep 2017]
Known Variants3 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs587672811 | 8:143,855,407 | C/A | — | — |
| rs34798388 | 8:143,857,096 | G/A | synonymous variant | — |
| rs564656629 | 8:143,859,616 | A/G | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.