LYRM4

LYR motif containing 4

Summary

The protein encoded by this gene is found in both mitochondria and the nucleus, where it binds cysteine desulfurase and helps free inorganic sulfur for Fe/S clusters. Disruption of this gene negatively impacts mitochondrial and cytosolic iron homeostasis. [provided by RefSeq, Sep 2016]

Known Variants65 total

rsidPosition (GRCh37)AllelesClassClinVar
rs93926536:5,071,492C/Tupstream gene variant—
rs96066:5,109,592T/G—benign
rs24810286706:5,109,648C/T—likely benign
rs1860473196:5,109,650C/T—likely benign
rs24810291056:5,109,704A/C—uncertain significance
rs7485270566:5,109,718A/G—uncertain significance
rs24810292686:5,109,730A/G—likely benign
rs4347066:5,109,945C/T—benign
rs557237706:5,109,981C/T—benign
rs122023846:5,109,998C/A—benign
rs1911721626:5,110,916G/Tintron variant—
rs12443963066:5,138,960T/C—likely benign
rs1423432436:5,144,188A/G—likely benign
rs4452046:5,144,189T/C—benign
rs3991206:5,144,192C/T—benign
rs1157538036:5,144,342C/G—benign
rs12607385836:5,144,423C/G—uncertain significance
rs13602948536:5,144,443G/C—uncertain significance
rs2008646:5,144,667C/T—benign
rs1122701886:5,144,740G/A—benign
rs5722837226:5,178,466G/T——
rs737197356:5,186,771C/G—likely benign
rs10554156:5,186,900G/T—benign
rs1822203196:5,186,939C/T—likely benign
rs1480121426:5,186,960G/A—likely benign
rs10003291626:5,187,054C/A—uncertain significance
rs7560384046:5,187,135T/C—uncertain significance
rs5595036836:5,187,172C/A—uncertain significance
rs715558866:5,216,650C/T—benign
rs1408606166:5,216,833A/G—benign
rs5877772186:5,216,855C/Tmissense variantpathogenic
rs7627843626:5,216,858C/T—uncertain significance
rs3752312116:5,216,871G/A—uncertain significance
rs25336169706:5,216,876C/T—uncertain significance
rs7740843556:5,216,882G/C—uncertain significance
rs7591326586:5,216,886T/C—uncertain significance
rs25336170806:5,216,889T/G—uncertain significance
rs25336173706:5,216,934C/T—uncertain significance
rs3774875776:5,216,949T/G—likely benign
rs1393001256:5,216,952T/C—uncertain significance
rs7813693246:5,216,965A/G—likely benign
rs413028516:5,217,010C/T—benign
rs132170776:5,217,068T/C—benign
rs171398096:5,217,082C/T—benign
rs1157362256:5,260,633C/T—likely benign
rs1115574656:5,260,694T/C—benign
rs1146662466:5,260,751C/G—benign
rs77522036:5,260,812C/G—benign
rs41417616:5,260,816A/G—benign
rs7493003616:5,260,892G/A—likely benign
rs15619113896:5,260,904C/G—uncertain significance
rs5471370676:5,260,927G/A—uncertain significance
rs12612688146:5,260,933G/C—uncertain significance
rs7747970576:5,260,934A/C—likely benign
rs5360774706:5,260,948C/T—uncertain significance
rs3718039666:5,260,959G/A—uncertain significance
rs13011427426:5,260,960C/T—uncertain significance
rs5373695286:5,261,012A/G—likely benign
rs22243926:5,261,136G/A—benign
rs1166704196:5,261,263C/T—benign
rs131910126:5,261,292G/A—benign
rs1164404186:5,261,308T/G—benign
rs97848706:5,261,359A/G—benign
rs3758467276:5,261,388C/T—likely benign
rs95043686:5,261,460A/C—benign

Gene information from NCBI Gene. Variant classifications from ClinVar.

LYRM4 — LYR motif containing 4