MAEL
maelstrom spermatogenic transposon silencer
Summary
Predicted to enable sequence-specific DNA binding activity. Predicted to be involved in male meiotic nuclear division; negative regulation of macromolecule biosynthetic process; and spermatogenesis. Predicted to act upstream of or within several processes, including homologous chromosome pairing at meiosis; intrinsic apoptotic signaling pathway in response to DNA damage; and negative regulation of macromolecule biosynthetic process. Predicted to be located in piP-body. Predicted to be active in P granule and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants22 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs6669886 | 1:166,956,710 | T/C | upstream gene variant | — |
| rs1397202631 | 1:166,958,599 | C/T | — | uncertain significance |
| rs755136215 | 1:166,958,647 | C/G | — | uncertain significance |
| rs144606344 | 1:166,958,987 | A/G | — | uncertain significance |
| rs768269478 | 1:166,959,016 | C/G | — | uncertain significance |
| rs545584688 | 1:166,959,391 | T/A | — | — |
| rs2525282964 | 1:166,960,664 | A/G | — | uncertain significance |
| rs1411103872 | 1:166,960,676 | C/T | — | uncertain significance |
| rs769923622 | 1:166,961,970 | G/A | — | uncertain significance |
| rs113109340 | 1:166,961,995 | A/G | — | benign |
| rs199624416 | 1:166,963,277 | G/A | — | uncertain significance |
| rs765569672 | 1:166,973,446 | A/C | — | uncertain significance |
| rs140068242 | 1:166,973,510 | A/T | — | uncertain significance |
| rs76161896 | 1:166,973,528 | C/A | — | benign |
| rs1664846196 | 1:166,974,552 | C/A | — | uncertain significance |
| rs898422350 | 1:166,974,588 | C/T | — | likely pathogenic |
| rs776583710 | 1:166,985,485 | T/C | — | uncertain significance |
| rs757249676 | 1:166,985,522 | G/C | — | likely pathogenic |
| rs2525373255 | 1:166,987,106 | G/C | — | uncertain significance |
| rs144722963 | 1:166,987,126 | C/T | — | uncertain significance |
| rs369912892 | 1:166,990,388 | A/G | — | uncertain significance |
| rs149589757 | 1:166,990,992 | A/G | — | likely benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.