MAL2
mal, T cell differentiation protein 2
Summary
This gene encodes a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It is required for transcytosis, an intracellular transport pathway used to deliver membrane-bound proteins and exogenous cargos from the basolateral to the apical surface. [provided by RefSeq, Jul 2008]
Known Variants6 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1197359200 | 8:120,220,722 | G/T | — | uncertain significance |
| rs1179836198 | 8:120,220,754 | G/A | — | uncertain significance |
| rs1364705 | 8:120,224,806 | A/G | downstream gene variant | — |
| rs574214679 | 8:120,244,723 | A/G | — | — |
| rs774988366 | 8:120,252,541 | A/G | — | uncertain significance |
| rs183744316 | 8:120,257,833 | G/A | 3 prime UTR variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.