MAP1LC3A
microtubule associated protein 1 light chain 3 alpha
Summary
MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene. The expression of variant 1 is suppressed in many tumor cell lines, suggesting that may be involved in carcinogenesis. [provided by RefSeq, Feb 2012]
Known Variants9 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs6088523 | 20:33,135,550 | C/G | intron variant | — |
| rs6120675 | 20:33,138,870 | T/C | intron variant | — |
| rs148065651 | 20:33,140,573 | G/A | intron variant | — |
| rs141609464 | 20:33,140,790 | C/T | intron variant | — |
| rs6058078 | 20:33,142,823 | G/C | intron variant | — |
| rs1040747 | 20:33,145,832 | C/G | downstream gene variant | — |
| rs760887166 | 20:33,147,029 | G/A | — | uncertain significance |
| rs2516155769 | 20:33,147,563 | C/T | — | uncertain significance |
| rs201519741 | 20:33,147,698 | T/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.