MAPK15
mitogen-activated protein kinase 15
Summary
Enables MAP kinase activity and chromatin binding activity. Involved in several processes, including dopamine uptake; protein localization to ciliary transition zone; and regulation of organelle organization. Located in several cellular components, including Golgi apparatus; autophagosome; and microtubule organizing center. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Apr 2025]
Known Variants55 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs372568132 | 8:144,798,611 | G/A | — | uncertain significance |
| rs45495391 | 8:144,799,903 | G/A | — | likely benign |
| rs141770552 | 8:144,799,912 | G/A | — | uncertain significance |
| rs1330750361 | 8:144,799,916 | C/T | — | uncertain significance |
| rs140275267 | 8:144,800,421 | G/C | — | uncertain significance |
| rs2538613967 | 8:144,800,437 | A/C | — | uncertain significance |
| rs368459044 | 8:144,800,954 | T/C | — | uncertain significance |
| rs2538618410 | 8:144,800,963 | T/C | — | uncertain significance |
| rs782069530 | 8:144,800,969 | G/A | — | uncertain significance |
| rs375622398 | 8:144,800,977 | G/A | — | uncertain significance |
| rs375351575 | 8:144,800,998 | G/A | — | uncertain significance |
| rs782256408 | 8:144,801,002 | G/C | — | uncertain significance |
| rs2538618961 | 8:144,801,016 | C/A | — | uncertain significance |
| rs1359322005 | 8:144,801,026 | G/A | — | likely benign |
| rs577107750 | 8:144,801,064 | C/G | — | uncertain significance |
| rs782239626 | 8:144,801,065 | G/C | — | uncertain significance |
| rs782084585 | 8:144,801,196 | G/C | — | uncertain significance |
| rs139710965 | 8:144,801,230 | T/A | — | uncertain significance |
| rs151138393 | 8:144,801,320 | C/A | — | likely benign |
| rs1554619266 | 8:144,801,571 | G/A | — | uncertain significance |
| rs149319950 | 8:144,801,589 | G/A | — | uncertain significance |
| rs139010308 | 8:144,801,595 | T/A | — | uncertain significance |
| rs1554619285 | 8:144,801,604 | C/T | — | uncertain significance |
| rs537644016 | 8:144,801,635 | C/T | — | uncertain significance |
| rs35925379 | 8:144,802,456 | C/T | missense variant | — |
| rs200749268 | 8:144,802,878 | G/C | — | uncertain significance |
| rs782747708 | 8:144,802,941 | G/A | — | uncertain significance |
| rs141379949 | 8:144,802,959 | C/T | — | uncertain significance |
| rs185466475 | 8:144,802,967 | C/T | — | uncertain significance |
| rs782214797 | 8:144,802,968 | G/C | — | uncertain significance |
| rs782636164 | 8:144,803,003 | G/A | — | uncertain significance |
| rs781962011 | 8:144,803,186 | G/A | — | uncertain significance |
| rs370712189 | 8:144,803,199 | G/A | — | uncertain significance |
| rs375851848 | 8:144,803,258 | C/T | — | uncertain significance |
| rs782338338 | 8:144,803,264 | C/T | — | uncertain significance |
| rs374408984 | 8:144,803,428 | G/A | — | uncertain significance |
| rs201591856 | 8:144,803,435 | C/T | — | uncertain significance |
| rs782315097 | 8:144,803,447 | G/C | — | uncertain significance |
| rs200752759 | 8:144,803,455 | G/A | — | uncertain significance |
| rs140439631 | 8:144,803,494 | G/C | — | likely benign |
| rs371482487 | 8:144,803,497 | G/A | — | uncertain significance |
| rs374710085 | 8:144,803,516 | G/A | — | uncertain significance |
| rs34115313 | 8:144,803,531 | G/A | — | benign |
| rs782580278 | 8:144,803,745 | C/T | — | uncertain significance |
| rs781913233 | 8:144,803,770 | T/C | — | uncertain significance |
| rs199585686 | 8:144,803,809 | G/A | — | uncertain significance |
| rs781983437 | 8:144,803,819 | A/T | — | uncertain significance |
| rs200756292 | 8:144,803,821 | C/T | — | uncertain significance |
| rs782531535 | 8:144,803,949 | C/G | — | uncertain significance |
| rs1209697851 | 8:144,804,004 | G/T | — | uncertain significance |
| rs200370966 | 8:144,804,016 | G/A | — | uncertain significance |
| rs782706794 | 8:144,804,254 | C/T | — | uncertain significance |
| rs200198011 | 8:144,804,272 | C/T | — | uncertain significance |
| rs924630192 | 8:144,804,282 | G/A | — | uncertain significance |
| rs781835294 | 8:144,804,408 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.