MAPK3

mitogen-activated protein kinase 3

Summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008]

Known Variants26 total

rsidPosition (GRCh37)AllelesClassClinVar
rs76530392716:30,127,996G/T—uncertain significance
rs75604783316:30,128,021G/A—uncertain significance
rs4129169616:30,128,167C/T—benign
rs52748196016:30,128,222G/A—uncertain significance
rs114369516:30,128,224C/T—likely benign
rs20220711816:30,128,241C/G—uncertain significance
rs5585913316:30,128,265C/T—likely benign
rs207296283616:30,128,274T/C—uncertain significance
rs117256346216:30,128,322G/A—uncertain significance
rs6176421616:30,129,103G/A—likely benign
rs13995727616:30,129,377C/A—likely benign
rs14256049016:30,129,736G/A—likely benign
rs254370707716:30,129,770T/C—likely pathogenic
rs159688035216:30,129,796G/A—likely benign
rs7856418716:30,131,777G/Aintron variant—
rs15110012116:30,133,171C/T—likely benign
rs77882687916:30,133,269C/G—uncertain significance
rs37438790016:30,133,335G/A—likely benign
rs88976866416:30,134,367A/G—uncertain significance
rs119755936316:30,134,405G/T—uncertain significance
rs139403533716:30,134,419C/A—uncertain significance
rs254371490216:30,134,462C/T—likely benign
rs76692258516:30,134,488G/A—likely benign
rs136857581616:30,134,498G/C—likely benign
rs2852940316:30,134,656T/A——
rs6176420216:30,134,679C/Tregulatory region variant—

Gene information from NCBI Gene. Variant classifications from ClinVar.