MAPK6
mitogen-activated protein kinase 6
Summary
The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008]
Known Variants25 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs189698618 | 15:52,271,281 | C/T | regulatory region variant | — |
| rs7162115 | 15:52,291,273 | G/A | — | — |
| rs1031529869 | 15:52,307,323 | G/C | — | — |
| rs1003338661 | 15:52,339,132 | T/C | — | uncertain significance |
| rs375629911 | 15:52,342,287 | C/G | — | uncertain significance |
| rs368830524 | 15:52,342,307 | A/T | — | uncertain significance |
| rs750081816 | 15:52,350,896 | G/A | — | uncertain significance |
| rs199765167 | 15:52,350,912 | C/A | — | uncertain significance |
| rs141979362 | 15:52,353,556 | A/C | — | uncertain significance |
| rs2542871309 | 15:52,353,661 | T/C | — | uncertain significance |
| rs751681991 | 15:52,353,664 | A/G | — | uncertain significance |
| rs2542885005 | 15:52,356,110 | G/C | — | uncertain significance |
| rs1293063988 | 15:52,356,245 | A/G | — | uncertain significance |
| rs755817710 | 15:52,356,248 | G/A | — | uncertain significance |
| rs1326333441 | 15:52,356,278 | A/C | — | uncertain significance |
| rs138879227 | 15:52,356,284 | A/G | — | likely benign |
| rs190252061 | 15:52,356,374 | C/A | — | uncertain significance |
| rs2542888076 | 15:52,356,575 | C/G | — | uncertain significance |
| rs1254814283 | 15:52,356,577 | G/A | — | uncertain significance |
| rs2032332416 | 15:52,356,640 | C/G | — | uncertain significance |
| rs1417471855 | 15:52,356,796 | T/C | — | uncertain significance |
| rs144209444 | 15:52,356,860 | T/C | — | uncertain significance |
| rs148363441 | 15:52,356,995 | G/A | — | uncertain significance |
| rs889695827 | 15:52,357,001 | A/G | — | uncertain significance |
| rs528265673 | 15:52,357,114 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.