MARK4
microtubule affinity regulating kinase 4
Summary
This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Known Variants50 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1233457397 | 19:45,754,879 | C/A | — | uncertain significance |
| rs151165225 | 19:45,760,920 | C/T | intron variant | — |
| rs188624748 | 19:45,761,361 | A/T | intron variant | — |
| rs757101512 | 19:45,762,271 | T/A | — | uncertain significance |
| rs1970345780 | 19:45,762,272 | C/T | — | uncertain significance |
| rs201262565 | 19:45,762,323 | G/A | — | uncertain significance |
| rs758021513 | 19:45,762,334 | G/A | — | uncertain significance |
| rs1274946963 | 19:45,766,582 | C/G | — | uncertain significance |
| rs756211354 | 19:45,768,122 | C/T | — | uncertain significance |
| rs377723607 | 19:45,769,491 | G/A | — | uncertain significance |
| rs768910204 | 19:45,769,513 | A/C | — | uncertain significance |
| rs968227279 | 19:45,774,800 | C/T | — | uncertain significance |
| rs34784381 | 19:45,774,858 | G/A | — | benign |
| rs200509853 | 19:45,781,176 | T/C | — | benign |
| rs770478941 | 19:45,781,250 | A/G | — | uncertain significance |
| rs190127005 | 19:45,781,623 | G/C | intron variant | — |
| rs1396436634 | 19:45,783,666 | A/C | — | uncertain significance |
| rs779413121 | 19:45,783,882 | C/T | — | uncertain significance |
| rs755396651 | 19:45,783,969 | G/A | — | uncertain significance |
| rs1201016192 | 19:45,790,714 | C/T | — | uncertain significance |
| rs1568500532 | 19:45,790,723 | C/T | — | uncertain significance |
| rs753148066 | 19:45,790,747 | C/T | — | uncertain significance |
| rs1039550856 | 19:45,790,780 | G/A | — | uncertain significance |
| rs377173611 | 19:45,790,798 | C/T | — | uncertain significance |
| rs148301412 | 19:45,790,811 | C/T | — | benign |
| rs1970762128 | 19:45,790,873 | C/T | — | uncertain significance |
| rs372480258 | 19:45,797,661 | C/T | — | uncertain significance |
| rs554206425 | 19:45,797,662 | G/A | — | uncertain significance |
| rs1265597749 | 19:45,797,676 | C/T | — | uncertain significance |
| rs771693803 | 19:45,797,680 | C/T | — | uncertain significance |
| rs201834748 | 19:45,797,691 | C/T | — | uncertain significance |
| rs778304169 | 19:45,800,986 | C/T | — | uncertain significance |
| rs1391975984 | 19:45,801,031 | C/T | — | uncertain significance |
| rs555456890 | 19:45,801,049 | G/A | — | uncertain significance |
| rs752380003 | 19:45,801,058 | C/T | — | uncertain significance |
| rs763492742 | 19:45,801,064 | C/T | — | uncertain significance |
| rs750746729 | 19:45,801,090 | G/T | — | uncertain significance |
| rs2123109797 | 19:45,801,130 | C/T | — | uncertain significance |
| rs376422468 | 19:45,801,154 | G/A | — | uncertain significance |
| rs540971776 | 19:45,801,160 | C/T | — | uncertain significance |
| rs1970910734 | 19:45,801,175 | A/C | — | uncertain significance |
| rs11672923 | 19:45,802,022 | C/T | intron variant | — |
| rs200323133 | 19:45,805,742 | G/A | — | uncertain significance |
| rs760675146 | 19:45,805,759 | G/A | — | uncertain significance |
| rs1430302829 | 19:45,805,853 | A/C | — | uncertain significance |
| rs548639038 | 19:45,805,883 | G/A | — | uncertain significance |
| rs1053052298 | 19:45,805,943 | G/A | — | uncertain significance |
| rs2513946217 | 19:45,805,951 | A/C | — | uncertain significance |
| rs756693005 | 19:45,805,952 | A/G | — | uncertain significance |
| rs2395 | 19:45,806,609 | A/C | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.