MARS1

methionyl-tRNA synthetase 1

Summary

This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. The encoded protein is a component of the multi-tRNA synthetase complex and catalyzes the ligation of methionine to tRNA molecules. [provided by RefSeq, Jan 2011]

Known Variants644 total

rsidPosition (GRCh37)AllelesClassClinVar
rs20153553112:57,881,856C/T—uncertain significance
rs76019438012:57,881,875T/A—uncertain significance
rs116606333712:57,881,878G/C—uncertain significance
rs58777722712:57,881,886G/A—uncertain significance
rs76638513012:57,881,900C/G—likely benign
rs75162022912:57,881,903G/A—likely benign
rs75030946712:57,881,904G/A—uncertain significance
rs187558358912:57,881,911T/C—uncertain significance
rs14400282712:57,881,915G/T—likely benign
rs18895589712:57,881,919C/G—likely benign
rs20047130412:57,881,939C/T—likely benign
rs213999347012:57,881,940C/G—uncertain significance
rs124780988412:57,881,941G/A—uncertain significance
rs122753127412:57,881,943G/A—uncertain significance
rs77146132812:57,881,944G/C—uncertain significance
rs132012451912:57,881,945C/T—likely benign
rs187558960812:57,881,946A/G—uncertain significance
rs156563570912:57,881,952G/A—uncertain significance
rs36918067212:57,881,959T/C—uncertain significance
rs75580746412:57,881,960C/T—likely benign
rs141215441112:57,881,962T/G—uncertain significance
rs1154080912:57,881,968C/G—uncertain significance
rs187559406912:57,881,971T/C—uncertain significance
rs254024884712:57,881,982G/A—uncertain significance
rs37272243812:57,882,000G/C—likely benign
rs254024895012:57,882,001G/T—likely benign
rs50890412:57,882,094A/G—benign
rs5572787912:57,882,776T/A—benign
rs213999667612:57,882,789A/T—likely benign
rs11354925612:57,882,792C/T—likely benign
rs74911064812:57,882,797A/C—likely benign
rs56474256812:57,882,807G/A—uncertain significance
rs187570415112:57,882,810G/A—uncertain significance
rs77500049412:57,882,812C/T—likely benign
rs254025421012:57,882,815G/C—likely benign
rs254025423612:57,882,818C/T—likely benign
rs155516536112:57,882,824C/T—likely benign
rs75956719312:57,882,826G/A—uncertain significance
rs76732612412:57,882,829C/G—uncertain significance
rs101835855612:57,882,836C/A—likely benign
rs187570745312:57,882,839T/C—likely benign
rs254025440312:57,882,840G/A—uncertain significance
rs187570894512:57,882,855A/G—uncertain significance
rs54078190912:57,882,857C/G—uncertain significance
rs254025456312:57,882,866C/T—likely benign
rs14864296112:57,882,872C/T—likely benign
rs93285450712:57,882,880G/A—uncertain significance
rs128522347612:57,882,892G/A—uncertain significance
rs77424158112:57,882,896A/G—uncertain significance
rs36960846412:57,882,903G/A—likely benign
rs76422123412:57,882,910G/A—likely benign
rs74700298312:57,883,030G/A—likely benign
rs101209694512:57,883,034C/T—likely benign
rs89032629412:57,883,036C/G—uncertain significance
rs20153190812:57,883,037T/C—likely benign
rs159480597712:57,883,040C/T—likely benign
rs132459360312:57,883,043T/G—likely benign
rs37488086012:57,883,047C/T—uncertain significance
rs254025589112:57,883,073G/A—pathogenic
rs254025589912:57,883,076A/C—uncertain significance
rs36931314112:57,883,077G/T—uncertain significance
rs14215301712:57,883,080A/G—likely benign
rs19059862212:57,883,087C/T—likely benign
rs75805176012:57,883,093A/C—uncertain significance
rs254025608112:57,883,114G/A—uncertain significance
rs78106156812:57,883,115C/T—uncertain significance
rs138677959312:57,883,122G/A—likely benign
rs95805884112:57,883,126C/T—uncertain significance
rs77125644012:57,883,133G/A—uncertain significance
rs254025626512:57,883,145G/A—likely benign
rs213999752312:57,883,146G/A—likely benign
rs14102057812:57,883,189A/G—likely benign
rs18319596012:57,883,193C/T—likely benign
rs37528103512:57,883,194C/T—likely benign
rs145814680512:57,883,195C/A—likely benign
rs74810166312:57,883,207C/T—uncertain significance
rs91604274512:57,883,222G/T—uncertain significance
rs20070123512:57,883,225C/G—uncertain significance
rs159480640012:57,883,227G/T—likely benign
rs91284749112:57,883,230C/G—uncertain significance
rs97317885912:57,883,235T/C—uncertain significance
rs127513280812:57,883,238T/A—uncertain significance
rs254025679312:57,883,241T/C—uncertain significance
rs77129946712:57,883,246G/A—uncertain significance
rs103740040212:57,883,250A/G—conflicting classifications of pathogenicity
rs77465526612:57,883,255G/C—uncertain significance
rs74623796012:57,883,257G/T—likely benign
rs37678564212:57,883,258G/C—uncertain significance
rs254025703712:57,883,264G/T—uncertain significance
rs213999787012:57,883,270G/A—uncertain significance
rs76113111012:57,883,276G/A—uncertain significance
rs15119699412:57,883,279C/T—uncertain significance
rs14139753012:57,883,280G/A—uncertain significance
rs254025712912:57,883,286C/T—uncertain significance
rs121116105612:57,883,290G/C—likely benign
rs20100722312:57,883,292C/A—uncertain significance
rs14529279312:57,883,296C/T—likely benign
rs11391759212:57,883,298T/C—uncertain significance
rs104628275512:57,883,306A/G—uncertain significance
rs77912981912:57,883,316G/C—uncertain significance

Showing 100 of 644 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.