MCHR1
melanin concentrating hormone receptor 1
Summary
The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. [provided by RefSeq, Jul 2008]
Known Variants43 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs133069 | 22:41,074,462 | A/G | — | — |
| rs1415705811 | 22:41,075,454 | C/T | — | uncertain significance |
| rs771384523 | 22:41,075,483 | A/G | — | uncertain significance |
| rs202245704 | 22:41,075,504 | G/A | — | likely benign |
| rs117372135 | 22:41,075,523 | C/T | — | likely benign |
| rs565709738 | 22:41,075,528 | G/C | — | uncertain significance |
| rs112405400 | 22:41,075,532 | A/T | — | benign |
| rs150937708 | 22:41,075,535 | C/G | — | uncertain significance |
| rs133072 | 22:41,075,543 | A/G | missense variant | — |
| rs150069806 | 22:41,075,562 | C/T | — | uncertain significance |
| rs146628737 | 22:41,075,588 | C/G | — | likely benign |
| rs2518278766 | 22:41,075,595 | A/C | — | uncertain significance |
| rs146834583 | 22:41,075,615 | A/T | — | uncertain significance |
| rs201605955 | 22:41,075,625 | G/A | — | uncertain significance |
| rs199936867 | 22:41,075,640 | C/T | — | uncertain significance |
| rs756610480 | 22:41,075,720 | G/A | — | uncertain significance |
| rs142851281 | 22:41,075,733 | C/T | — | uncertain significance |
| rs11914085 | 22:41,076,970 | G/A | — | benign |
| rs199847547 | 22:41,077,011 | C/T | — | likely benign |
| rs143942609 | 22:41,077,066 | G/A | — | uncertain significance |
| rs987667577 | 22:41,077,152 | G/C | — | likely benign |
| rs757056931 | 22:41,077,177 | C/T | — | uncertain significance |
| rs778664994 | 22:41,077,180 | A/G | — | uncertain significance |
| rs1244208432 | 22:41,077,192 | G/T | — | uncertain significance |
| rs145237086 | 22:41,077,343 | C/T | — | uncertain significance |
| rs2518281379 | 22:41,077,363 | T/C | — | uncertain significance |
| rs762669619 | 22:41,077,400 | C/T | — | uncertain significance |
| rs137903389 | 22:41,077,548 | C/T | — | benign |
| rs149149384 | 22:41,077,549 | G/A | — | uncertain significance |
| rs1425832610 | 22:41,077,568 | A/G | — | uncertain significance |
| rs182594063 | 22:41,077,612 | C/T | — | uncertain significance |
| rs45439291 | 22:41,077,613 | G/A | — | likely benign |
| rs2056881984 | 22:41,077,708 | T/G | — | uncertain significance |
| rs200939549 | 22:41,077,725 | G/A | — | likely benign |
| rs36115367 | 22:41,077,734 | C/T | — | likely benign |
| rs200535551 | 22:41,077,754 | C/T | — | uncertain significance |
| rs138438808 | 22:41,077,786 | C/T | — | uncertain significance |
| rs201321975 | 22:41,077,821 | G/A | — | likely benign |
| rs199555247 | 22:41,077,844 | C/T | — | uncertain significance |
| rs200253261 | 22:41,077,873 | C/T | — | uncertain significance |
| rs149604804 | 22:41,077,895 | C/T | — | likely benign |
| rs1409004434 | 22:41,077,900 | G/A | — | uncertain significance |
| rs2056883738 | 22:41,077,904 | A/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.