MEPE
matrix extracellular phosphoglycoprotein
Summary
This gene encodes a secreted calcium-binding phosphoprotein that belongs to the small integrin-binding ligand, N-linked glycoprotein (SIBLING) family of proteins. Members of this family are components of the extracellular matrix of bone and dentin and regulate bone mineralization. Deficiency of a similar protein in mouse results in increased bone mass. Mice lacking this gene are resistant to aging-related trabecular bone loss. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Known Variants62 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs4345135 | 4:88,750,208 | T/C | intron variant | — |
| rs7698623 | 4:88,755,828 | T/C | intron variant | — |
| rs6857656 | 4:88,759,344 | A/G | regulatory region variant | — |
| rs1389510940 | 4:88,759,808 | A/C | — | uncertain significance |
| rs17013282 | 4:88,765,873 | G/A | regulatory region variant | — |
| rs138665285 | 4:88,766,142 | A/T | — | benign |
| rs577867340 | 4:88,766,156 | G/T | — | uncertain significance |
| rs141864614 | 4:88,766,197 | A/G | — | likely benign |
| rs758921551 | 4:88,766,268 | G/A | — | uncertain significance |
| rs372153135 | 4:88,766,285 | T/C | — | uncertain significance |
| rs769933388 | 4:88,766,316 | A/T | — | uncertain significance |
| rs201213159 | 4:88,766,373 | C/T | — | uncertain significance |
| rs754696980 | 4:88,766,385 | G/A | — | uncertain significance |
| rs139311420 | 4:88,766,404 | T/C | — | likely benign |
| rs148637496 | 4:88,766,450 | G/A | — | uncertain significance |
| rs753432480 | 4:88,766,499 | C/T | — | likely benign |
| rs752363823 | 4:88,766,510 | C/G | — | uncertain significance |
| rs748402314 | 4:88,766,588 | C/T | — | uncertain significance |
| rs370725784 | 4:88,766,600 | A/G | — | uncertain significance |
| rs115322331 | 4:88,766,636 | A/G | — | benign |
| rs369063049 | 4:88,766,637 | G/T | — | likely benign |
| rs147945998 | 4:88,766,678 | A/G | — | uncertain significance |
| rs548626494 | 4:88,766,687 | C/T | — | likely benign |
| rs200287337 | 4:88,766,701 | A/C | — | benign |
| rs150454926 | 4:88,766,737 | C/T | — | likely benign |
| rs767540653 | 4:88,766,738 | G/T | — | uncertain significance |
| rs200300679 | 4:88,766,795 | G/A | — | uncertain significance |
| rs1723207786 | 4:88,766,832 | C/T | — | uncertain significance |
| rs765908926 | 4:88,766,871 | G/T | — | uncertain significance |
| rs138823925 | 4:88,766,873 | T/C | — | likely benign |
| rs141911146 | 4:88,766,896 | G/A | — | likely benign |
| rs772909804 | 4:88,766,939 | C/T | — | uncertain significance |
| rs756004959 | 4:88,766,950 | A/C | — | uncertain significance |
| rs764644948 | 4:88,766,970 | T/C | — | uncertain significance |
| rs113931822 | 4:88,766,991 | C/T | — | likely benign |
| rs374783833 | 4:88,766,992 | G/A | — | likely benign |
| rs112583476 | 4:88,767,000 | C/A | — | uncertain significance |
| rs754920155 | 4:88,767,001 | A/G | — | likely benign |
| rs17013285 | 4:88,767,008 | A/G | — | benign |
| rs776051454 | 4:88,767,038 | G/A | — | uncertain significance |
| rs768327031 | 4:88,767,056 | A/C | — | uncertain significance |
| rs752690498 | 4:88,767,096 | A/G | — | uncertain significance |
| rs144470334 | 4:88,767,132 | A/G | — | uncertain significance |
| rs1298762366 | 4:88,767,150 | C/T | — | likely benign |
| rs139465355 | 4:88,767,173 | G/A | — | uncertain significance |
| rs79592550 | 4:88,767,191 | G/A | — | benign |
| rs1333010157 | 4:88,767,199 | T/A | — | not provided |
| rs78166851 | 4:88,767,205 | C/G | — | benign |
| rs74593863 | 4:88,767,260 | T/G | — | benign |
| rs1260733630 | 4:88,767,335 | C/G | — | uncertain significance |
| rs61731017 | 4:88,767,366 | A/C | — | benign |
| rs61731018 | 4:88,767,413 | C/A | — | benign |
| rs1468087643 | 4:88,767,431 | T/G | — | uncertain significance |
| rs149174816 | 4:88,767,432 | A/G | — | uncertain significance |
| rs61731015 | 4:88,767,461 | C/T | — | benign |
| rs781549826 | 4:88,767,474 | T/C | — | uncertain significance |
| rs2476174507 | 4:88,767,476 | C/A | — | uncertain significance |
| rs61731016 | 4:88,767,481 | A/C | — | benign |
| rs201756883 | 4:88,767,517 | C/A | — | uncertain significance |
| rs2476174822 | 4:88,767,519 | G/T | — | uncertain significance |
| rs749358196 | 4:88,767,554 | G/A | — | uncertain significance |
| rs527970865 | 4:88,767,575 | T/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.