MET
MET proto-oncogene, receptor tyrosine kinase
Summary
This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]
Known Variants2,839 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1858830 | 7:116,312,439 | C/G | regulatory region variant | benign |
| rs536603694 | 7:116,312,464 | C/A | — | benign |
| rs886061938 | 7:116,312,466 | C/A | — | uncertain significance |
| rs886061939 | 7:116,312,481 | C/G | — | uncertain significance |
| rs886061940 | 7:116,312,489 | T/G | — | uncertain significance |
| rs1796009308 | 7:116,312,537 | C/T | — | uncertain significance |
| rs555011707 | 7:116,312,565 | G/T | — | likely benign |
| rs886061941 | 7:116,312,580 | G/T | — | uncertain significance |
| rs866509744 | 7:116,312,582 | G/T | — | uncertain significance |
| rs1796012626 | 7:116,312,611 | C/G | — | uncertain significance |
| rs38845 | 7:116,321,802 | A/G | intron variant | — |
| rs77907624 | 7:116,328,654 | G/T | intron variant | — |
| rs80153920 | 7:116,335,811 | A/T | — | not provided |
| rs80048442 | 7:116,335,828 | G/C | — | not provided |
| rs38850 | 7:116,337,649 | G/A | intron variant | — |
| rs2116576794 | 7:116,339,099 | C/T | — | likely benign |
| rs36080330 | 7:116,339,112 | C/T | — | benign |
| rs2116577145 | 7:116,339,113 | C/G | — | likely benign |
| rs144126521 | 7:116,339,121 | G/A | — | likely benign |
| rs863224376 | 7:116,339,132 | T/C | — | likely benign |
| rs963663507 | 7:116,339,136 | A/T | — | uncertain significance |
| rs2116577569 | 7:116,339,137 | T/C | — | uncertain significance |
| rs1416393044 | 7:116,339,145 | G/A | — | conflicting classifications of pathogenicity |
| rs1797064164 | 7:116,339,146 | C/T | — | uncertain significance |
| rs1797064273 | 7:116,339,147 | C/T | — | likely benign |
| rs772251895 | 7:116,339,150 | C/T | — | likely benign |
| rs765444467 | 7:116,339,151 | G/A | — | conflicting classifications of pathogenicity |
| rs1395233386 | 7:116,339,154 | G/T | — | uncertain significance |
| rs950885374 | 7:116,339,155 | T/G | — | uncertain significance |
| rs2116578054 | 7:116,339,159 | T/G | — | likely benign |
| rs758564871 | 7:116,339,160 | G/A | — | conflicting classifications of pathogenicity |
| rs1797066204 | 7:116,339,162 | A/T | — | likely benign |
| rs2116578170 | 7:116,339,163 | C/A | — | uncertain significance |
| rs1355886011 | 7:116,339,164 | C/T | — | uncertain significance |
| rs2116578238 | 7:116,339,165 | T/G | — | likely benign |
| rs919828654 | 7:116,339,167 | G/A | — | uncertain significance |
| rs2116578320 | 7:116,339,168 | C/T | — | likely benign |
| rs1584875601 | 7:116,339,169 | A/G | — | uncertain significance |
| rs764455004 | 7:116,339,172 | C/A | — | uncertain significance |
| rs188625702 | 7:116,339,174 | C/T | — | likely benign |
| rs781777052 | 7:116,339,175 | G/A | — | conflicting classifications of pathogenicity |
| rs748776466 | 7:116,339,176 | T/C | — | uncertain significance |
| rs763344951 | 7:116,339,178 | C/T | — | conflicting classifications of pathogenicity |
| rs2116578695 | 7:116,339,180 | C/G | — | likely benign |
| rs2116578733 | 7:116,339,181 | C/T | — | likely benign |
| rs2116578774 | 7:116,339,182 | T/C | — | uncertain significance |
| rs778415960 | 7:116,339,183 | G/C | — | likely benign |
| rs2485504670 | 7:116,339,185 | T/G | — | uncertain significance |
| rs2116578892 | 7:116,339,186 | T/C | — | likely benign |
| rs747777018 | 7:116,339,188 | C/T | — | uncertain significance |
| rs1584875653 | 7:116,339,189 | C/T | — | likely benign |
| rs1260001540 | 7:116,339,190 | T/C | — | conflicting classifications of pathogenicity |
| rs1486187704 | 7:116,339,193 | G/C | — | uncertain significance |
| rs1584875673 | 7:116,339,195 | G/A | — | likely benign |
| rs2116579143 | 7:116,339,196 | C/A | — | uncertain significance |
| rs2116579265 | 7:116,339,199 | A/G | — | uncertain significance |
| rs964356368 | 7:116,339,200 | G/A | — | conflicting classifications of pathogenicity |
| rs587780739 | 7:116,339,203 | G/T | — | conflicting classifications of pathogenicity |
| rs773018125 | 7:116,339,204 | C/A | — | uncertain significance |
| rs2485504944 | 7:116,339,207 | T/C | — | likely benign |
| rs180985111 | 7:116,339,209 | G/A | — | conflicting classifications of pathogenicity |
| rs770829669 | 7:116,339,210 | G/A | — | likely benign |
| rs2116579525 | 7:116,339,211 | G/T | — | uncertain significance |
| rs925600985 | 7:116,339,213 | G/A | — | likely benign |
| rs2116579595 | 7:116,339,214 | T/C | — | uncertain significance |
| rs1584875719 | 7:116,339,215 | G/A | — | uncertain significance |
| rs2116579656 | 7:116,339,217 | A/T | — | uncertain significance |
| rs555920594 | 7:116,339,218 | A/G | — | conflicting classifications of pathogenicity |
| rs1562882876 | 7:116,339,220 | G/A | — | uncertain significance |
| rs2116579734 | 7:116,339,221 | A/T | — | uncertain significance |
| rs759602956 | 7:116,339,222 | G/C | — | uncertain significance |
| rs765246117 | 7:116,339,223 | G/T | — | uncertain significance |
| rs775439897 | 7:116,339,224 | C/G | — | uncertain significance |
| rs1584875753 | 7:116,339,225 | A/G | — | likely benign |
| rs1060504939 | 7:116,339,226 | C/T | — | likely benign |
| rs1797069603 | 7:116,339,227 | T/C | — | uncertain significance |
| rs2485505163 | 7:116,339,230 | C/T | — | conflicting classifications of pathogenicity |
| rs763196530 | 7:116,339,231 | A/G | — | likely benign |
| rs2116580040 | 7:116,339,234 | G/A | — | likely benign |
| rs2485505223 | 7:116,339,236 | C/A | — | uncertain significance |
| rs1363905218 | 7:116,339,237 | C/T | — | likely benign |
| rs764246939 | 7:116,339,238 | G/A | — | conflicting classifications of pathogenicity |
| rs1296330997 | 7:116,339,240 | G/C | — | uncertain significance |
| rs375353223 | 7:116,339,241 | A/T | — | conflicting classifications of pathogenicity |
| rs1584875799 | 7:116,339,242 | T/C | — | uncertain significance |
| rs376244358 | 7:116,339,243 | G/C | — | conflicting classifications of pathogenicity |
| rs1282716584 | 7:116,339,245 | A/G | — | uncertain significance |
| rs2116580390 | 7:116,339,246 | T/C | — | likely benign |
| rs863224692 | 7:116,339,247 | G/T | — | conflicting classifications of pathogenicity |
| rs201315884 | 7:116,339,248 | T/G | — | uncertain significance |
| rs863224693 | 7:116,339,252 | T/A | — | conflicting classifications of pathogenicity |
| rs879254330 | 7:116,339,254 | T/C | — | uncertain significance |
| rs2116580621 | 7:116,339,255 | G/A | — | uncertain significance |
| rs1210616219 | 7:116,339,257 | A/T | — | conflicting classifications of pathogenicity |
| rs780358093 | 7:116,339,260 | A/G | — | uncertain significance |
| rs199812384 | 7:116,339,261 | T/C | — | likely benign |
| rs2116580859 | 7:116,339,262 | C/A | — | uncertain significance |
| rs1167851500 | 7:116,339,264 | G/C | — | uncertain significance |
| rs1487106127 | 7:116,339,266 | T/C | — | uncertain significance |
| rs200641198 | 7:116,339,267 | T/C | — | likely benign |
Showing 100 of 2,839 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.