MGLL
monoglyceride lipase
Summary
This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Known Variants27 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs138910107 | 3:127,411,064 | C/T | — | likely benign |
| rs2075261232 | 3:127,411,070 | C/T | — | uncertain significance |
| rs748034490 | 3:127,411,110 | G/A | — | likely benign |
| rs2473451955 | 3:127,413,830 | G/C | — | uncertain significance |
| rs2473452265 | 3:127,413,878 | A/C | — | uncertain significance |
| rs4881 | 3:127,413,881 | T/C | — | benign |
| rs749613281 | 3:127,413,886 | G/A | — | uncertain significance |
| rs371817663 | 3:127,413,937 | C/T | — | uncertain significance |
| rs752505671 | 3:127,413,942 | T/G | — | uncertain significance |
| rs751040089 | 3:127,413,955 | C/T | — | uncertain significance |
| rs138122374 | 3:127,413,976 | C/T | — | likely benign |
| rs775337048 | 3:127,414,030 | C/T | — | uncertain significance |
| rs376576148 | 3:127,439,950 | C/T | — | uncertain significance |
| rs111794060 | 3:127,439,968 | C/T | — | benign |
| rs201835629 | 3:127,439,994 | C/T | — | likely benign |
| rs773791349 | 3:127,441,290 | G/A | — | uncertain significance |
| rs140105585 | 3:127,441,353 | C/T | — | likely benign |
| rs664910 | 3:127,474,030 | G/A | regulatory region variant | — |
| rs187497147 | 3:127,486,739 | C/T | intron variant | — |
| rs75396122 | 3:127,500,639 | G/A | — | benign |
| rs766837613 | 3:127,500,684 | C/G | — | uncertain significance |
| rs201794814 | 3:127,500,702 | G/A | — | benign |
| rs375239037 | 3:127,540,530 | G/C | — | likely benign |
| rs757049697 | 3:127,540,568 | A/C | — | uncertain significance |
| rs763430390 | 3:127,540,630 | G/A | — | uncertain significance |
| rs757569359 | 3:127,540,633 | G/A | — | uncertain significance |
| rs201175620 | 3:127,540,645 | G/A | — | benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.