MMP15
matrix metallopeptidase 15
Summary
This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein may play a role in cancer progression. [provided by RefSeq, Jan 2016]
Known Variants65 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs540813875 | 16:58,060,279 | G/A | — | uncertain significance |
| rs1293720909 | 16:58,060,286 | C/G | — | uncertain significance |
| rs1490460561 | 16:58,060,295 | C/G | — | uncertain significance |
| rs1002421077 | 16:58,060,301 | G/C | — | uncertain significance |
| rs2544740664 | 16:58,060,394 | A/C | — | uncertain significance |
| rs4784886 | 16:58,065,459 | G/A | intron variant | — |
| rs12924215 | 16:58,071,092 | C/T | intron variant | — |
| rs201766277 | 16:58,071,385 | C/T | — | uncertain significance |
| rs376179211 | 16:58,071,386 | G/A | — | uncertain significance |
| rs368255301 | 16:58,071,416 | G/A | — | uncertain significance |
| rs1024127600 | 16:58,071,430 | A/C | — | uncertain significance |
| rs199836131 | 16:58,071,511 | G/A | — | uncertain significance |
| rs766546091 | 16:58,072,186 | C/A | — | uncertain significance |
| rs747308827 | 16:58,072,210 | G/A | — | uncertain significance |
| rs774413461 | 16:58,072,217 | G/A | — | uncertain significance |
| rs759724145 | 16:58,072,235 | G/A | — | uncertain significance |
| rs768002784 | 16:58,073,793 | C/T | — | uncertain significance |
| rs543011167 | 16:58,073,832 | G/A | — | uncertain significance |
| rs780493873 | 16:58,073,843 | C/T | — | uncertain significance |
| rs776922953 | 16:58,073,872 | C/T | — | likely benign |
| rs148695510 | 16:58,073,900 | C/T | — | uncertain significance |
| rs142146192 | 16:58,073,901 | G/A | — | uncertain significance |
| rs139344353 | 16:58,073,915 | A/G | — | uncertain significance |
| rs2544746595 | 16:58,074,005 | T/G | — | uncertain significance |
| rs536687699 | 16:58,074,085 | T/A | — | uncertain significance |
| rs2544747041 | 16:58,074,549 | T/C | — | uncertain significance |
| rs148331048 | 16:58,074,569 | G/A | — | uncertain significance |
| rs12447804 | 16:58,075,282 | C/T | intron variant | — |
| rs114643486 | 16:58,075,570 | G/A | — | benign |
| rs746765714 | 16:58,075,598 | C/T | — | uncertain significance |
| rs369989245 | 16:58,075,599 | G/A | — | uncertain significance |
| rs544505738 | 16:58,075,604 | C/T | — | uncertain significance |
| rs1474817294 | 16:58,075,605 | C/T | — | uncertain significance |
| rs763559443 | 16:58,075,607 | C/T | — | uncertain significance |
| rs375076496 | 16:58,075,646 | C/T | — | uncertain significance |
| rs746816007 | 16:58,075,647 | G/A | — | uncertain significance |
| rs770073111 | 16:58,075,662 | G/T | — | uncertain significance |
| rs535498144 | 16:58,075,680 | G/A | — | uncertain significance |
| rs773394391 | 16:58,075,691 | C/T | — | uncertain significance |
| rs376327026 | 16:58,075,692 | G/A | — | uncertain significance |
| rs551256083 | 16:58,075,697 | G/A | — | uncertain significance |
| rs201216675 | 16:58,075,704 | A/G | — | uncertain significance |
| rs777828191 | 16:58,075,721 | G/A | — | uncertain significance |
| rs763672023 | 16:58,075,754 | G/T | — | uncertain significance |
| rs41334654 | 16:58,076,126 | C/T | — | benign |
| rs766382979 | 16:58,076,151 | G/A | — | uncertain significance |
| rs776535024 | 16:58,076,156 | C/T | — | uncertain significance |
| rs1959475647 | 16:58,076,258 | T/G | — | uncertain significance |
| rs769667733 | 16:58,077,141 | C/T | — | uncertain significance |
| rs1285772154 | 16:58,077,147 | T/A | — | uncertain significance |
| rs201800162 | 16:58,077,186 | T/C | — | uncertain significance |
| rs369041093 | 16:58,077,189 | G/A | — | uncertain significance |
| rs1959496802 | 16:58,077,424 | G/A | — | uncertain significance |
| rs879459351 | 16:58,078,934 | A/G | — | uncertain significance |
| rs148956674 | 16:58,078,968 | G/A | — | uncertain significance |
| rs749280786 | 16:58,079,001 | G/C | — | uncertain significance |
| rs748583150 | 16:58,079,030 | G/A | — | uncertain significance |
| rs745546321 | 16:58,079,043 | G/A | — | uncertain significance |
| rs1197238312 | 16:58,079,142 | T/C | — | likely benign |
| rs758947009 | 16:58,079,147 | G/T | — | uncertain significance |
| rs1020034929 | 16:58,079,197 | G/T | — | uncertain significance |
| rs200769934 | 16:58,079,216 | G/A | — | likely benign |
| rs1293428883 | 16:58,079,229 | T/A | — | uncertain significance |
| rs144513455 | 16:58,079,283 | A/G | — | uncertain significance |
| rs145052293 | 16:58,079,301 | C/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.