MNT
MAX network transcriptional repressor
Summary
The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain. [provided by RefSeq, Jul 2008]
Known Variants22 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1385219467 | 17:2,290,260 | C/T | — | uncertain significance |
| rs199839050 | 17:2,290,353 | C/G | — | uncertain significance |
| rs61753101 | 17:2,290,405 | C/T | — | benign |
| rs748638034 | 17:2,290,431 | C/T | — | uncertain significance |
| rs760150673 | 17:2,290,482 | T/C | — | uncertain significance |
| rs776457448 | 17:2,290,488 | G/A | — | uncertain significance |
| rs753145734 | 17:2,290,510 | C/G | — | likely benign |
| rs760843496 | 17:2,290,699 | T/C | — | likely benign |
| rs151061793 | 17:2,290,785 | G/A | — | uncertain significance |
| rs755234076 | 17:2,290,904 | C/T | — | likely benign |
| rs149297090 | 17:2,291,292 | G/A | — | uncertain significance |
| rs185455119 | 17:2,291,323 | C/T | — | benign |
| rs531961808 | 17:2,292,571 | T/C | — | — |
| rs997830320 | 17:2,298,175 | G/A | — | uncertain significance |
| rs561978070 | 17:2,298,217 | G/A | — | uncertain significance |
| rs751847898 | 17:2,298,310 | G/A | — | uncertain significance |
| rs776161708 | 17:2,298,400 | G/A | — | uncertain significance |
| rs1597421159 | 17:2,298,454 | A/G | — | uncertain significance |
| rs746319729 | 17:2,298,496 | G/A | — | uncertain significance |
| rs780335013 | 17:2,298,592 | G/A | — | uncertain significance |
| rs141569229 | 17:2,298,647 | G/A | — | uncertain significance |
| rs201879561 | 17:2,298,715 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.