MOG

myelin oligodendrocyte glycoprotein

Summary

The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Known Variants23 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs9461541	6:29,625,195	A/G	intron variant	—
rs2252711	6:29,626,321	T/C	intron variant	—
rs9468572	6:29,626,917	G/A	intron variant	—
rs563552917	6:29,627,125	C/A	—	uncertain significance
rs2481384823	6:29,627,138	T/C	—	uncertain significance
rs200284390	6:29,627,170	A/G	—	uncertain significance
rs1294315820	6:29,627,188	G/A	—	uncertain significance
rs529478745	6:29,627,203	G/A	—	uncertain significance
rs182420962	6:29,627,218	C/G	—	uncertain significance
rs138169338	6:29,627,222	C/A	—	likely benign
rs34758289	6:29,627,313	A/G	—	benign
rs376255591	6:29,627,351	G/A	—	uncertain significance
rs139424758	6:29,627,396	G/A	—	uncertain significance
rs387906655	6:29,627,405	C/G	missense variant	pathogenic
rs2535253	6:29,633,019	C/A	intron variant	—
rs2857766	6:29,634,003	G/C	missense variant	benign
rs3130253	6:29,634,012	G/A	—	benign
rs530778894	6:29,635,693	G/A	—	uncertain significance
rs112913018	6:29,638,101	T/A	—	uncertain significance
rs375219482	6:29,638,163	G/A	—	uncertain significance
rs370604035	6:29,638,563	A/G	—	likely benign
rs606231122	6:29,640,505	—	—	pathogenic
rs79020217	6:29,640,516	G/C	missense variant	pathogenic

Gene information from NCBI Gene. Variant classifications from ClinVar.