MORC2

MORC family CW-type zinc finger 2

Summary

This gene encodes a member of the Microrchidia (MORC) protein superfamily. The encoded protein is known to regulate the condensation of heterochromatin in response to DNA damage and play a role in repressing transcription. The protein has been found to regulate the activity of ATP citrate lyase via specific interaction with this enzyme in the cytosol of lipogenic breast cancer cells. The protein also plays a role in lipogenesis and adipocyte differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

Known Variants725 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs113471863	22:31,322,733	A/C	—	likely benign
rs2040491146	22:31,322,795	C/A	—	uncertain significance
rs2517552396	22:31,322,807	T/C	—	uncertain significance
rs149110760	22:31,322,808	G/T	—	likely benign
rs146032580	22:31,322,823	G/C	—	likely benign
rs12330040	22:31,322,825	C/T	—	uncertain significance
rs138812699	22:31,322,826	G/A	—	likely benign
rs746468192	22:31,322,843	T/C	—	uncertain significance
rs1342054043	22:31,322,858	C/T	—	likely pathogenic
rs373542143	22:31,322,862	G/C	—	conflicting classifications of pathogenicity
rs558377610	22:31,322,867	G/C	—	likely benign
rs764985949	22:31,322,873	G/T	—	likely benign
rs1296516776	22:31,322,877	G/A	—	likely benign
rs80056206	22:31,323,051	C/A	—	benign
rs9619154	22:31,323,784	G/A	—	benign
rs5753394	22:31,323,900	G/C	—	benign
rs2517556353	22:31,323,987	G/C	—	likely benign
rs200086094	22:31,323,997	C/G	—	benign
rs376367685	22:31,323,998	G/A	—	likely benign
rs766942597	22:31,323,999	G/A	—	likely benign
rs1388656367	22:31,324,000	G/C	—	uncertain significance
rs1202036526	22:31,324,008	C/G	—	uncertain significance
rs753896900	22:31,324,012	C/T	—	uncertain significance
rs765411579	22:31,324,021	C/G	—	likely benign
rs752921354	22:31,324,028	G/A	—	uncertain significance
rs2517556488	22:31,324,029	C/T	—	uncertain significance
rs778221935	22:31,324,032	C/T	—	uncertain significance
rs751315289	22:31,324,033	G/A	—	likely benign
rs2517556561	22:31,324,038	T/C	—	uncertain significance
rs142766430	22:31,324,047	G/A	—	benign
rs2147229264	22:31,324,050	T/A	—	uncertain significance
rs781327828	22:31,324,066	C/T	—	likely benign
rs745339848	22:31,324,067	G/A	—	uncertain significance
rs2517556694	22:31,324,068	T/G	—	uncertain significance
rs769387633	22:31,324,072	G/A	—	likely benign
rs747693260	22:31,324,073	C/T	—	uncertain significance
rs748910060	22:31,324,074	G/A	—	uncertain significance
rs924176973	22:31,324,084	C/T	—	likely benign
rs773617883	22:31,324,086	C/T	—	uncertain significance
rs372404658	22:31,324,087	G/A	—	likely benign
rs771410096	22:31,324,092	T/C	—	uncertain significance
rs1307310663	22:31,324,095	G/A	—	uncertain significance
rs376140991	22:31,324,108	G/A	—	likely benign
rs1569186001	22:31,324,112	G/T	—	uncertain significance
rs2147229542	22:31,324,115	T/A	—	uncertain significance
rs1278082078	22:31,324,121	C/T	—	uncertain significance
rs1485425350	22:31,324,122	G/A	—	uncertain significance
rs142559213	22:31,324,124	G/A	—	uncertain significance
rs892793528	22:31,324,129	A/G	—	likely benign
rs370918395	22:31,324,133	C/T	—	uncertain significance
rs764290080	22:31,324,134	G/A	—	uncertain significance
rs2517557184	22:31,324,140	G/A	—	uncertain significance
rs781162787	22:31,324,148	T/C	—	conflicting classifications of pathogenicity
rs750335952	22:31,324,156	G/C	—	uncertain significance
rs2517557345	22:31,324,184	A/C	—	uncertain significance
rs756131826	22:31,324,186	G/A	—	likely benign
rs1285225047	22:31,324,189	C/T	—	likely benign
rs2040519174	22:31,324,207	G/A	—	likely benign
rs551815983	22:31,328,113	G/C	—	likely benign
rs192723178	22:31,328,326	G/A	—	likely benign
rs781471605	22:31,328,327	A/G	—	likely benign
rs1260253974	22:31,328,328	A/T	—	likely benign
rs2517568285	22:31,328,348	G/C	—	uncertain significance
rs1162268371	22:31,328,360	T/C	—	uncertain significance
rs1349107983	22:31,328,374	T/C	—	uncertain significance
rs2517568390	22:31,328,377	A/G	—	uncertain significance
rs1602477274	22:31,328,385	C/A	—	likely benign
rs2147240279	22:31,328,389	T/G	—	uncertain significance
rs1413895387	22:31,328,391	C/A	—	uncertain significance
rs2517568565	22:31,328,408	A/G	—	uncertain significance
rs768569356	22:31,328,411	T/C	—	uncertain significance
rs185390451	22:31,328,420	G/A	—	likely benign
rs762057484	22:31,328,428	C/T	—	uncertain significance
rs767914603	22:31,328,433	A/G	—	benign
rs1231700799	22:31,328,436	A/G	—	likely benign
rs1602477344	22:31,328,442	A/G	—	uncertain significance
rs760591381	22:31,328,454	G/T	—	likely benign
rs1453840865	22:31,328,513	A/G	—	likely benign
rs376197429	22:31,328,516	C/A	—	likely benign
rs1602477488	22:31,328,518	A/G	—	likely benign
rs368417146	22:31,328,526	A/G	—	uncertain significance
rs974685925	22:31,328,532	C/T	—	uncertain significance
rs751197811	22:31,328,540	C/T	—	likely benign
rs2517569133	22:31,328,541	T/C	—	uncertain significance
rs1569188333	22:31,328,545	C/A	—	uncertain significance
rs11549247	22:31,328,549	C/G	—	likely benign
rs770586964	22:31,328,554	C/T	—	uncertain significance
rs147997704	22:31,328,555	G/A	—	likely benign
rs2147240880	22:31,328,560	T/A	—	uncertain significance
rs765227719	22:31,328,564	G/A	—	likely benign
rs1042426757	22:31,328,568	T/C	—	likely benign
rs141374674	22:31,328,570	G/A	—	likely benign
rs762499940	22:31,328,571	G/C	—	uncertain significance
rs141633101	22:31,328,574	C/G	—	likely benign
rs1555936530	22:31,328,581	C/A	—	uncertain significance
rs371685129	22:31,328,594	C/T	—	likely benign
rs2517569484	22:31,328,595	T/C	—	uncertain significance
rs1376706321	22:31,328,599	T/C	—	uncertain significance
rs202243108	22:31,328,601	C/G	—	uncertain significance
rs150496681	22:31,328,602	G/A	—	conflicting classifications of pathogenicity

Showing 100 of 725 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.