MORC4
MORC family CW-type zinc finger 4
Summary
In human, the four current members of the microrchidia (morc) gene family share an N-terminal ATPase-like ATP-binding region and a CW four-cysteine zinc-finger motif. The protein encoded by this gene also has a nuclear matrix binding domain and a two-stranded coiled-coil motif near its C-terminus. This gene is widely expressed at low levels in normal tissues and has elevated expression in placenta and testis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jan 2010]
Known Variants40 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs12014762 | X:106,183,670 | C/T | downstream gene variant | — |
| rs1351911254 | X:106,185,232 | G/A | — | uncertain significance |
| rs772143288 | X:106,185,235 | T/C | — | uncertain significance |
| rs1437597311 | X:106,185,244 | C/T | — | uncertain significance |
| rs752110087 | X:106,185,363 | G/A | — | uncertain significance |
| rs373809376 | X:106,185,823 | C/A | — | uncertain significance |
| rs779541314 | X:106,185,888 | T/A | — | uncertain significance |
| rs150736453 | X:106,185,911 | G/A | — | uncertain significance |
| rs139105737 | X:106,185,951 | C/T | — | benign |
| rs150263726 | X:106,186,159 | C/T | — | benign |
| rs557687749 | X:106,186,163 | C/T | — | likely benign |
| rs146759137 | X:106,186,291 | G/C | — | uncertain significance |
| rs760479375 | X:106,186,305 | G/T | — | uncertain significance |
| rs781759399 | X:106,186,365 | G/A | — | uncertain significance |
| rs774049936 | X:106,198,259 | C/G | — | uncertain significance |
| rs775673203 | X:106,198,276 | C/T | — | uncertain significance |
| rs746224109 | X:106,199,720 | T/C | — | uncertain significance |
| rs6622126 | X:106,200,202 | G/A | missense variant | — |
| rs1256711768 | X:106,205,246 | T/C | — | uncertain significance |
| rs1002826564 | X:106,205,291 | T/G | — | uncertain significance |
| rs769101240 | X:106,205,333 | T/C | — | uncertain significance |
| rs961640852 | X:106,221,338 | G/A | — | uncertain significance |
| rs2521867463 | X:106,221,379 | C/G | — | uncertain significance |
| rs2521867532 | X:106,221,393 | T/C | — | uncertain significance |
| rs374513815 | X:106,224,137 | T/A | — | uncertain significance |
| rs761617610 | X:106,224,146 | T/C | — | uncertain significance |
| rs2521873216 | X:106,224,666 | T/G | — | uncertain significance |
| rs2030843585 | X:106,224,706 | T/C | — | uncertain significance |
| rs762630243 | X:106,228,404 | C/T | — | uncertain significance |
| rs201795914 | X:106,228,405 | G/A | — | uncertain significance |
| rs773446384 | X:106,228,456 | C/T | — | uncertain significance |
| rs1934863824 | X:106,229,313 | A/C | — | uncertain significance |
| rs758644429 | X:106,229,334 | G/A | — | likely benign |
| rs1935015064 | X:106,236,575 | C/T | — | uncertain significance |
| rs2521905580 | X:106,242,977 | C/A | — | uncertain significance |
| rs770202249 | X:106,243,147 | A/T | — | uncertain significance |
| rs1935151100 | X:106,243,154 | A/C | — | uncertain significance |
| rs761899546 | X:106,243,181 | C/A | — | uncertain significance |
| rs2521906458 | X:106,243,189 | T/G | — | uncertain significance |
| rs12688220 | X:106,244,767 | C/T | upstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.