MPO
myeloperoxidase
Summary
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]
Known Variants88 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs113203253 | 17:56,348,068 | G/A | — | likely benign |
| rs1175389434 | 17:56,348,073 | C/A | — | uncertain significance |
| rs61747608 | 17:56,348,122 | G/A | — | benign |
| rs1302344396 | 17:56,348,130 | T/A | — | uncertain significance |
| rs139752741 | 17:56,348,142 | C/T | — | uncertain significance |
| rs35702888 | 17:56,348,208 | C/G | — | uncertain significance |
| rs35897051 | 17:56,348,226 | T/G | splice region variant | pathogenic |
| rs2071409 | 17:56,348,230 | G/T | — | benign |
| rs201720064 | 17:56,349,050 | C/G | — | uncertain significance |
| rs182814920 | 17:56,349,062 | C/T | — | uncertain significance |
| rs766368829 | 17:56,349,073 | C/T | — | uncertain significance |
| rs774394797 | 17:56,349,077 | C/A | — | uncertain significance |
| rs544802395 | 17:56,349,095 | G/A | — | likely benign |
| rs368505308 | 17:56,349,111 | G/A | — | likely benign |
| rs112737382 | 17:56,349,122 | T/G | — | likely benign |
| rs143204664 | 17:56,349,128 | T/C | — | uncertain significance |
| rs2509139200 | 17:56,349,231 | G/T | — | uncertain significance |
| rs35670089 | 17:56,349,236 | G/A | — | likely benign |
| rs774984207 | 17:56,350,118 | C/T | — | uncertain significance |
| rs1970383257 | 17:56,350,121 | G/A | — | uncertain significance |
| rs753062060 | 17:56,350,132 | C/T | — | uncertain significance |
| rs757914812 | 17:56,350,163 | C/T | — | uncertain significance |
| rs119469012 | 17:56,350,186 | A/C | missense variant | pathogenic |
| rs773478778 | 17:56,350,190 | G/A | — | likely pathogenic |
| rs119468010 | 17:56,350,196 | G/A | missense variant | pathogenic |
| rs144371238 | 17:56,350,258 | C/T | — | uncertain significance |
| rs148802625 | 17:56,350,259 | G/A | — | uncertain significance |
| rs200618562 | 17:56,350,265 | T/C | — | uncertain significance |
| rs1555607599 | 17:56,350,773 | A/G | — | likely pathogenic |
| rs1170768560 | 17:56,350,861 | A/G | — | uncertain significance |
| rs1359512785 | 17:56,350,868 | A/G | — | uncertain significance |
| rs119469013 | 17:56,350,895 | C/T | missense variant | pathogenic |
| rs119469014 | 17:56,350,901 | G/A | missense variant | pathogenic |
| rs756572859 | 17:56,350,925 | C/T | — | uncertain significance |
| rs778272248 | 17:56,350,926 | G/A | — | likely benign |
| rs61095987 | 17:56,350,986 | C/T | — | benign |
| rs149133270 | 17:56,351,017 | C/T | — | conflicting classifications of pathogenicity |
| rs28730835 | 17:56,351,019 | G/A | — | benign |
| rs773011655 | 17:56,351,029 | A/G | — | uncertain significance |
| rs8082134 | 17:56,352,626 | G/T | intron variant | — |
| rs182011210 | 17:56,352,896 | G/A | — | likely benign |
| rs56261212 | 17:56,352,995 | G/A | — | uncertain significance |
| rs371556942 | 17:56,353,018 | G/T | — | uncertain significance |
| rs34212101 | 17:56,354,640 | G/C | — | — |
| rs148905487 | 17:56,355,211 | G/A | — | likely benign |
| rs780416471 | 17:56,355,353 | C/T | — | uncertain significance |
| rs1970460686 | 17:56,355,361 | C/T | — | uncertain significance |
| rs28730837 | 17:56,355,397 | G/A | missense variant | pathogenic |
| rs1402515798 | 17:56,355,496 | T/C | — | uncertain significance |
| rs372446639 | 17:56,356,398 | C/A | — | uncertain significance |
| rs1031444685 | 17:56,356,428 | C/T | — | uncertain significance |
| rs1970476683 | 17:56,356,439 | C/T | — | uncertain significance |
| rs374576463 | 17:56,356,440 | G/A | — | uncertain significance |
| rs759684602 | 17:56,356,497 | T/C | — | uncertain significance |
| rs56378716 | 17:56,356,502 | A/G | missense variant | pathogenic |
| rs750849138 | 17:56,356,523 | G/A | — | uncertain significance |
| rs754632893 | 17:56,356,533 | G/A | — | pathogenic |
| rs749120180 | 17:56,356,558 | G/C | — | uncertain significance |
| rs1476706511 | 17:56,356,568 | G/C | — | uncertain significance |
| rs1192615702 | 17:56,356,569 | C/T | — | uncertain significance |
| rs760201363 | 17:56,356,728 | T/G | — | uncertain significance |
| rs778013714 | 17:56,356,732 | C/A | — | conflicting classifications of pathogenicity |
| rs773436729 | 17:56,356,765 | A/T | — | uncertain significance |
| rs78950939 | 17:56,356,914 | T/C | missense variant | pathogenic |
| rs372243533 | 17:56,356,915 | A/G | — | uncertain significance |
| rs140392145 | 17:56,356,937 | C/A | — | likely benign |
| rs576727865 | 17:56,356,974 | G/A | — | uncertain significance |
| rs146782684 | 17:56,356,983 | T/A | — | uncertain significance |
| rs1970491533 | 17:56,357,202 | G/A | — | uncertain significance |
| rs181494077 | 17:56,357,221 | G/A | — | pathogenic |
| rs1970491995 | 17:56,357,222 | C/T | — | likely pathogenic |
| rs369052644 | 17:56,357,243 | C/G | — | uncertain significance |
| rs138269172 | 17:56,357,309 | C/T | — | likely benign |
| rs772856090 | 17:56,357,310 | G/A | — | uncertain significance |
| rs762526880 | 17:56,357,377 | T/C | — | likely pathogenic |
| rs375300978 | 17:56,357,718 | G/A | — | likely benign |
| rs149590233 | 17:56,357,741 | C/T | — | likely benign |
| rs957962698 | 17:56,357,751 | T/C | — | uncertain significance |
| rs752277567 | 17:56,357,796 | G/A | — | uncertain significance |
| rs55929952 | 17:56,357,803 | C/T | — | benign |
| rs7208693 | 17:56,357,818 | C/A | missense variant | benign |
| rs2856857 | 17:56,357,833 | G/A | intron variant | — |
| rs560564165 | 17:56,358,008 | C/A | — | uncertain significance |
| rs1555608302 | 17:56,358,010 | A/G | — | uncertain significance |
| rs140215981 | 17:56,358,073 | C/T | — | likely benign |
| rs1598044103 | 17:56,358,175 | G/A | — | not provided |
| rs2333227 | 17:56,358,762 | C/T | upstream gene variant | risk factor |
| rs2243828 | 17:56,358,884 | A/T | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.