MS4A1

membrane spanning 4-domains A1

Summary

This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]

Known Variants141 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs533120064	11:60,225,304	T/C	—	—
rs17155019	11:60,229,677	C/T	—	benign
rs2135197109	11:60,229,856	A/G	—	likely benign
rs200768099	11:60,229,857	C/T	—	uncertain significance
rs763588373	11:60,229,882	T/A	—	uncertain significance
rs143807889	11:60,229,885	C/T	—	uncertain significance
rs34109768	11:60,229,886	G/A	—	likely benign
rs766227660	11:60,229,887	G/A	—	uncertain significance
rs1409066613	11:60,229,889	A/G	—	likely benign
rs2135197184	11:60,229,892	G/T	—	likely benign
rs768892705	11:60,229,894	C/T	—	uncertain significance
rs754610368	11:60,229,895	A/G	—	likely benign
rs201491900	11:60,229,897	T/C	—	uncertain significance
rs752311016	11:60,229,898	G/A	—	uncertain significance
rs2495398622	11:60,229,902	G/T	—	uncertain significance
rs2135197222	11:60,229,906	C/T	—	uncertain significance
rs1273768917	11:60,229,907	T/C	—	likely benign
rs2135197243	11:60,229,912	C/A	—	uncertain significance
rs1343328268	11:60,229,913	T/C	—	likely benign
rs1204983091	11:60,229,914	A/G	—	uncertain significance
rs201354938	11:60,229,917	C/T	—	uncertain significance
rs2495398726	11:60,229,921	C/A	—	uncertain significance
rs1453889572	11:60,229,924	G/T	—	uncertain significance
rs2135197301	11:60,229,933	C/T	—	uncertain significance
rs747239876	11:60,229,945	G/A	—	uncertain significance
rs2495399013	11:60,229,957	T/G	—	uncertain significance
rs200805059	11:60,229,958	G/C	—	benign
rs1322248141	11:60,229,962	G/A	—	uncertain significance
rs773222759	11:60,229,966	C/A	—	uncertain significance
rs2135197406	11:60,229,968	A/T	—	uncertain significance
rs147754874	11:60,229,969	C/T	—	uncertain significance
rs150061756	11:60,229,970	G/A	—	benign
rs2086256871	11:60,230,004	G/C	—	uncertain significance
rs200587336	11:60,230,016	T/C	—	likely benign
rs1186395780	11:60,230,025	A/G	—	likely benign
rs185920494	11:60,230,457	C/G	—	likely benign
rs2495401411	11:60,230,468	T/A	—	likely benign
rs200724174	11:60,230,471	C/T	—	likely benign
rs1473555726	11:60,230,495	G/A	—	likely benign
rs775234557	11:60,230,498	C/T	—	likely benign
rs2135198098	11:60,230,505	A/G	—	uncertain significance
rs146626926	11:60,230,509	C/T	—	uncertain significance
rs1396948389	11:60,230,513	G/T	—	likely benign
rs1289003304	11:60,230,521	T/C	—	uncertain significance
rs79703274	11:60,230,523	C/T	—	benign
rs1237057005	11:60,230,530	T/A	—	uncertain significance
rs2070770	11:60,230,531	C/T	—	benign
rs558358265	11:60,230,541	A/T	—	uncertain significance
rs199747240	11:60,230,550	C/A	—	uncertain significance
rs116433863	11:60,230,577	C/A	—	likely benign
rs1167602115	11:60,230,588	C/A	—	likely benign
rs2135198311	11:60,230,595	G/A	—	uncertain significance
rs10792278	11:60,230,722	T/G	—	benign
rs7126354	11:60,231,066	C/A	—	—
rs2086272243	11:60,231,741	C/T	—	likely benign
rs201962059	11:60,231,772	C/T	—	likely benign
rs371479947	11:60,231,773	G/A	—	uncertain significance
rs201665706	11:60,231,792	C/T	—	uncertain significance
rs200265912	11:60,231,793	G/A	—	likely benign
rs267603055	11:60,231,796	G/C	—	uncertain significance
rs201361363	11:60,231,809	A/G	—	uncertain significance
rs768359203	11:60,231,825	A/T	—	likely benign
rs372476401	11:60,231,827	C/T	—	likely benign
rs202216356	11:60,231,829	T/C	—	likely benign
rs775881428	11:60,231,834	C/A	—	likely benign
rs377012945	11:60,231,835	C/T	—	likely benign
rs4146870	11:60,231,986	A/G	—	benign
rs4939364	11:60,232,325	A/T	—	—
rs2135201495	11:60,233,394	G/A	—	uncertain significance
rs777259260	11:60,233,401	G/A	—	uncertain significance
rs201245387	11:60,233,409	A/C	—	uncertain significance
rs199860984	11:60,233,410	T/C	—	uncertain significance
rs1672351032	11:60,233,450	G/T	—	uncertain significance
rs2495410326	11:60,233,454	C/A	—	uncertain significance
rs2495410337	11:60,233,462	C/T	—	likely benign
rs2086288211	11:60,233,505	G/C	—	uncertain significance
rs201495118	11:60,233,512	T/C	—	uncertain significance
rs2495410646	11:60,233,532	A/G	—	uncertain significance
rs757004270	11:60,233,533	C/T	—	uncertain significance
rs745437493	11:60,233,538	T/G	—	uncertain significance
rs2495410724	11:60,233,551	A/T	—	uncertain significance
rs1190819313	11:60,233,579	G/A	—	likely benign
rs201784186	11:60,233,589	C/T	—	uncertain significance
rs2135201874	11:60,233,590	C/T	—	uncertain significance
rs547604951	11:60,233,594	T/C	—	likely benign
rs778670251	11:60,233,596	C/A	—	uncertain significance
rs1359452268	11:60,233,602	A/G	—	uncertain significance
rs2495411036	11:60,233,603	C/T	—	likely benign
rs1292673417	11:60,233,610	A/T	—	uncertain significance
rs375847581	11:60,233,613	A/C	—	uncertain significance
rs779655185	11:60,233,614	T/C	—	uncertain significance
rs1350279662	11:60,233,631	G/T	—	uncertain significance
rs201826314	11:60,233,634	A/G	—	uncertain significance
rs2495411281	11:60,233,648	G/A	—	uncertain significance
rs2495411287	11:60,233,649	T/A	—	likely benign
rs2135203040	11:60,234,448	T/C	—	uncertain significance
rs184174552	11:60,234,455	C/G	—	uncertain significance
rs2495413906	11:60,234,466	T/G	—	uncertain significance
rs2495413989	11:60,234,478	T/G	—	uncertain significance
rs2495414017	11:60,234,482	A/G	—	uncertain significance

Showing 100 of 141 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.