MS4A12
membrane spanning 4-domains A12
Summary
The protein encoded by this gene is a cell surface protein found primarily in the apical membrane of colonocytes. Silencing of this gene in colon cancer cells inhibits the proliferation, cell motility, and chemotactic invasion of cells. This gene is part of a cluster of similar genes found on chromosome 11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Known Variants25 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs72928718 | 11:60,264,001 | G/A | intron variant | — |
| rs1195128504 | 11:60,264,797 | G/T | — | uncertain significance |
| rs2495462443 | 11:60,264,798 | T/C | — | uncertain significance |
| rs746776765 | 11:60,264,852 | C/A | — | uncertain significance |
| rs137894801 | 11:60,264,933 | C/T | — | uncertain significance |
| rs545246635 | 11:60,264,934 | G/A | — | uncertain significance |
| rs775828292 | 11:60,264,955 | C/T | — | uncertain significance |
| rs143911504 | 11:60,264,956 | A/G | — | likely benign |
| rs1481324190 | 11:60,265,000 | T/C | — | likely benign |
| rs769148565 | 11:60,265,032 | G/A | — | uncertain significance |
| rs7939177 | 11:60,266,070 | C/T | intron variant | — |
| rs7933244 | 11:60,267,695 | T/A | — | — |
| rs201589223 | 11:60,268,555 | T/C | — | uncertain significance |
| rs1299493410 | 11:60,268,591 | G/A | — | uncertain significance |
| rs2495471613 | 11:60,268,606 | T/A | — | uncertain significance |
| rs111546873 | 11:60,269,505 | G/A | — | uncertain significance |
| rs6591594 | 11:60,271,173 | G/T | — | benign |
| rs773888916 | 11:60,271,181 | G/A | — | uncertain significance |
| rs1590863027 | 11:60,271,201 | G/A | — | uncertain significance |
| rs374195006 | 11:60,271,243 | G/A | — | uncertain significance |
| rs147819793 | 11:60,274,226 | C/T | — | likely benign |
| rs765251191 | 11:60,274,292 | C/T | — | uncertain significance |
| rs780675530 | 11:60,274,524 | G/C | — | uncertain significance |
| rs768853841 | 11:60,274,536 | C/T | — | uncertain significance |
| rs766347364 | 11:60,274,587 | C/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.