MST1
macrophage stimulating 1
Summary
The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds. [provided by RefSeq, Jan 2010]
Known Variants62 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2544637811 | 3:49,721,466 | C/T | — | uncertain significance |
| rs778105210 | 3:49,721,531 | C/T | — | uncertain significance |
| rs1409390985 | 3:49,721,549 | C/T | — | uncertain significance |
| rs758285582 | 3:49,721,577 | C/T | — | uncertain significance |
| rs141594671 | 3:49,721,592 | T/C | — | uncertain significance |
| rs200268600 | 3:49,721,622 | C/T | — | uncertain significance |
| rs199810403 | 3:49,721,797 | C/G | — | uncertain significance |
| rs774171044 | 3:49,721,806 | G/T | — | uncertain significance |
| rs138155786 | 3:49,721,811 | C/T | — | uncertain significance |
| rs142690032 | 3:49,721,812 | G/A | — | benign |
| rs1277030290 | 3:49,721,826 | C/T | — | uncertain significance |
| rs2544640949 | 3:49,721,863 | T/G | — | uncertain significance |
| rs761248104 | 3:49,722,175 | C/T | — | uncertain significance |
| rs1302511480 | 3:49,722,186 | A/G | — | uncertain significance |
| rs200492732 | 3:49,722,292 | C/T | — | uncertain significance |
| rs760656029 | 3:49,722,464 | G/A | — | uncertain significance |
| rs375438838 | 3:49,722,701 | C/T | — | uncertain significance |
| rs149138392 | 3:49,722,706 | G/A | — | likely benign |
| rs142344838 | 3:49,722,759 | A/G | — | uncertain significance |
| rs149255516 | 3:49,722,765 | G/A | — | conflicting classifications of pathogenicity |
| rs2544648877 | 3:49,722,779 | T/C | — | uncertain significance |
| rs138040954 | 3:49,722,795 | A/G | — | uncertain significance |
| rs774015694 | 3:49,722,910 | G/A | — | uncertain significance |
| rs545162253 | 3:49,722,911 | G/T | — | likely benign |
| rs368282760 | 3:49,722,922 | A/G | — | uncertain significance |
| rs757386956 | 3:49,723,061 | G/A | — | uncertain significance |
| rs374627079 | 3:49,723,073 | A/G | — | likely benign |
| rs1223154186 | 3:49,723,076 | G/A | — | uncertain significance |
| rs746368594 | 3:49,723,099 | A/G | — | likely benign |
| rs528893815 | 3:49,723,116 | G/A | — | uncertain significance |
| rs62262683 | 3:49,723,147 | T/C | synonymous variant | — |
| rs774351585 | 3:49,723,317 | G/A | — | uncertain significance |
| rs149086566 | 3:49,723,376 | C/T | — | likely benign |
| rs1264949446 | 3:49,723,384 | C/A | — | uncertain significance |
| rs2053706386 | 3:49,723,503 | C/T | — | uncertain significance |
| rs373326765 | 3:49,723,518 | C/T | — | uncertain significance |
| rs774026528 | 3:49,723,521 | C/G | — | uncertain significance |
| rs751808918 | 3:49,723,548 | C/T | — | uncertain significance |
| rs2544657819 | 3:49,723,579 | G/A | — | uncertain significance |
| rs774919205 | 3:49,723,602 | C/T | — | uncertain significance |
| rs2544661323 | 3:49,723,770 | A/T | — | uncertain significance |
| rs9713651 | 3:49,723,784 | C/A | — | likely benign |
| rs7431215 | 3:49,723,823 | A/G | — | likely benign |
| rs561615522 | 3:49,723,845 | C/T | — | uncertain significance |
| rs753354867 | 3:49,723,855 | C/T | — | uncertain significance |
| rs375422702 | 3:49,723,859 | C/A | — | uncertain significance |
| rs761582221 | 3:49,723,913 | C/A | — | likely benign |
| rs148805329 | 3:49,724,465 | C/G | — | benign |
| rs780476426 | 3:49,724,686 | T/C | — | uncertain significance |
| rs1477399027 | 3:49,724,799 | G/C | — | uncertain significance |
| rs2053865322 | 3:49,724,813 | A/G | — | uncertain significance |
| rs1159873166 | 3:49,724,903 | G/C | — | uncertain significance |
| rs745729745 | 3:49,725,009 | C/T | — | uncertain significance |
| rs1292497022 | 3:49,725,043 | A/G | — | uncertain significance |
| rs373890576 | 3:49,725,207 | C/T | — | uncertain significance |
| rs201139383 | 3:49,725,234 | A/C | — | uncertain significance |
| rs781505169 | 3:49,725,253 | C/T | — | uncertain significance |
| rs1437124540 | 3:49,725,267 | T/A | — | uncertain significance |
| rs752572365 | 3:49,725,294 | C/T | — | uncertain significance |
| rs62262686 | 3:49,726,070 | G/A | — | uncertain significance |
| rs1281501452 | 3:49,726,103 | C/T | — | uncertain significance |
| rs2544680683 | 3:49,726,114 | C/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.