MTREX
Mtr4 exosome RNA helicase
Summary
Enables ATP binding activity and RNA helicase activity. Involved in DNA damage response; RNA catabolic process; and maturation of 5.8S rRNA. Located in nuclear exosome (RNase complex) and nucleoplasm. Part of TRAMP complex and catalytic step 2 spliceosome. Biomarker of amyotrophic lateral sclerosis. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants49 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs373476345 | 5:54,603,873 | G/A | — | uncertain significance |
| rs181975111 | 5:54,603,884 | G/A | — | likely benign |
| rs16884049 | 5:54,603,898 | T/G | — | benign |
| rs2478880899 | 5:54,603,950 | C/A | — | uncertain significance |
| rs564104416 | 5:54,603,960 | C/T | — | uncertain significance |
| rs1331926951 | 5:54,618,189 | A/G | — | uncertain significance |
| rs376118901 | 5:54,618,192 | A/C | — | uncertain significance |
| rs2478917953 | 5:54,618,259 | C/T | — | uncertain significance |
| rs762676968 | 5:54,619,964 | G/A | — | uncertain significance |
| rs2478923623 | 5:54,619,968 | A/G | — | uncertain significance |
| rs750512165 | 5:54,619,998 | T/G | — | uncertain significance |
| rs1256319903 | 5:54,637,557 | G/C | — | uncertain significance |
| rs777746852 | 5:54,639,233 | A/G | — | uncertain significance |
| rs747521885 | 5:54,639,246 | G/A | — | uncertain significance |
| rs2478964043 | 5:54,639,267 | G/T | — | uncertain significance |
| rs1173404117 | 5:54,639,276 | A/G | — | uncertain significance |
| rs2478964054 | 5:54,639,278 | A/G | — | uncertain significance |
| rs770390480 | 5:54,641,007 | G/A | — | uncertain significance |
| rs755253071 | 5:54,642,871 | T/G | — | uncertain significance |
| rs2478971898 | 5:54,642,877 | T/C | — | uncertain significance |
| rs2478976510 | 5:54,645,415 | A/G | — | uncertain significance |
| rs765284840 | 5:54,645,433 | A/G | — | uncertain significance |
| rs144334570 | 5:54,645,457 | G/A | — | uncertain significance |
| rs148783802 | 5:54,646,772 | A/G | — | uncertain significance |
| rs141523339 | 5:54,649,046 | A/G | — | likely benign |
| rs559425071 | 5:54,651,417 | G/A | — | — |
| rs1439245651 | 5:54,654,473 | A/G | — | uncertain significance |
| rs1579873373 | 5:54,662,674 | A/G | — | uncertain significance |
| rs143136046 | 5:54,674,235 | A/G | — | uncertain significance |
| rs139182599 | 5:54,674,963 | T/C | — | likely benign |
| rs144065455 | 5:54,674,967 | G/A | — | uncertain significance |
| rs754297100 | 5:54,674,970 | G/T | — | uncertain significance |
| rs1750505285 | 5:54,683,803 | C/G | — | uncertain significance |
| rs1441065580 | 5:54,683,847 | C/A | — | uncertain significance |
| rs757482394 | 5:54,693,314 | G/A | — | uncertain significance |
| rs756196849 | 5:54,693,319 | G/A | — | uncertain significance |
| rs755494298 | 5:54,696,067 | C/G | — | uncertain significance |
| rs114771389 | 5:54,696,126 | A/G | — | benign |
| rs2479081685 | 5:54,696,140 | A/G | — | uncertain significance |
| rs147032648 | 5:54,696,199 | A/T | — | uncertain significance |
| rs143871302 | 5:54,696,224 | A/G | — | uncertain significance |
| rs200255625 | 5:54,701,332 | G/A | — | uncertain significance |
| rs977735900 | 5:54,706,443 | G/C | — | uncertain significance |
| rs2479107468 | 5:54,710,022 | C/T | — | uncertain significance |
| rs1579904051 | 5:54,711,808 | A/C | — | uncertain significance |
| rs1579904055 | 5:54,711,814 | T/C | — | uncertain significance |
| rs753847285 | 5:54,711,950 | T/A | — | uncertain significance |
| rs201555046 | 5:54,718,793 | A/C | — | uncertain significance |
| rs761596187 | 5:54,720,570 | T/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.