MVP
major vault protein
Summary
This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
Known Variants70 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs12149746 | 16:29,832,873 | A/C | — | — |
| rs185910551 | 16:29,834,697 | A/G | downstream gene variant | — |
| rs9938630 | 16:29,837,108 | C/T | regulatory region variant | — |
| rs4788186 | 16:29,841,225 | A/G | regulatory region variant | — |
| rs142997389 | 16:29,841,950 | G/A | — | benign |
| rs775063563 | 16:29,841,980 | G/A | — | uncertain significance |
| rs374182340 | 16:29,842,218 | C/T | — | uncertain significance |
| rs148190767 | 16:29,842,230 | G/A | — | likely benign |
| rs146206640 | 16:29,842,240 | G/A | — | uncertain significance |
| rs201797714 | 16:29,842,273 | G/A | — | uncertain significance |
| rs142974213 | 16:29,842,318 | G/A | — | uncertain significance |
| rs763814505 | 16:29,842,378 | G/A | — | uncertain significance |
| rs767445178 | 16:29,845,087 | A/T | — | uncertain significance |
| rs2543368229 | 16:29,845,145 | T/A | — | uncertain significance |
| rs777830582 | 16:29,845,167 | C/T | — | likely benign |
| rs902238887 | 16:29,845,264 | A/C | — | uncertain significance |
| rs144701925 | 16:29,845,271 | G/A | — | likely benign |
| rs370201976 | 16:29,845,334 | G/T | — | uncertain significance |
| rs147696965 | 16:29,845,355 | G/T | — | uncertain significance |
| rs2543369034 | 16:29,845,381 | G/A | — | uncertain significance |
| rs1392283893 | 16:29,847,046 | C/G | — | uncertain significance |
| rs748778623 | 16:29,847,093 | G/A | — | uncertain significance |
| rs779823147 | 16:29,848,065 | G/C | — | uncertain significance |
| rs773587439 | 16:29,848,076 | C/T | — | uncertain significance |
| rs2543373814 | 16:29,848,118 | C/G | — | uncertain significance |
| rs779656687 | 16:29,848,145 | C/T | — | uncertain significance |
| rs71389430 | 16:29,848,154 | G/C | — | conflicting classifications of pathogenicity |
| rs137947788 | 16:29,848,162 | C/T | — | likely benign |
| rs2067492257 | 16:29,848,222 | T/G | — | uncertain significance |
| rs758288435 | 16:29,848,226 | G/A | — | uncertain significance |
| rs368451204 | 16:29,848,239 | C/T | — | uncertain significance |
| rs2067492591 | 16:29,848,242 | A/C | — | uncertain significance |
| rs1326842881 | 16:29,848,249 | G/C | — | uncertain significance |
| rs1391067088 | 16:29,851,517 | C/T | — | uncertain significance |
| rs112014410 | 16:29,851,558 | G/A | — | benign |
| rs1239321397 | 16:29,851,619 | G/C | — | uncertain significance |
| rs150899988 | 16:29,851,667 | C/T | — | uncertain significance |
| rs758676231 | 16:29,852,920 | C/T | — | uncertain significance |
| rs779647852 | 16:29,852,921 | G/A | — | uncertain significance |
| rs2543381158 | 16:29,852,933 | G/C | — | uncertain significance |
| rs147232925 | 16:29,852,968 | T/A | — | uncertain significance |
| rs2543381398 | 16:29,853,065 | A/G | — | uncertain significance |
| rs541296428 | 16:29,853,074 | C/T | — | uncertain significance |
| rs773150912 | 16:29,853,097 | G/A | — | uncertain significance |
| rs371618386 | 16:29,853,298 | T/C | — | uncertain significance |
| rs749930422 | 16:29,853,303 | G/A | — | uncertain significance |
| rs754616199 | 16:29,853,319 | G/A | — | uncertain significance |
| rs757781726 | 16:29,853,331 | G/A | — | uncertain significance |
| rs958350171 | 16:29,855,816 | A/T | — | uncertain significance |
| rs200748000 | 16:29,855,890 | G/A | — | uncertain significance |
| rs146078848 | 16:29,855,968 | C/T | — | uncertain significance |
| rs2543385254 | 16:29,856,002 | C/A | — | uncertain significance |
| rs371042454 | 16:29,856,005 | C/T | — | likely benign |
| rs144055211 | 16:29,856,036 | G/A | — | likely benign |
| rs147256190 | 16:29,856,046 | C/T | — | uncertain significance |
| rs1012547196 | 16:29,856,067 | C/A | — | uncertain significance |
| rs35916172 | 16:29,856,082 | G/A | — | benign |
| rs954970546 | 16:29,856,146 | G/A | — | uncertain significance |
| rs1434955364 | 16:29,856,170 | T/C | — | uncertain significance |
| rs2067570518 | 16:29,856,194 | C/T | — | uncertain significance |
| rs139289305 | 16:29,857,215 | C/T | — | uncertain significance |
| rs201522490 | 16:29,857,231 | G/A | — | uncertain significance |
| rs371613615 | 16:29,857,479 | C/T | — | likely benign |
| rs562114790 | 16:29,857,526 | G/A | — | uncertain significance |
| rs539956095 | 16:29,859,163 | C/T | — | likely benign |
| rs2543388272 | 16:29,859,164 | T/C | — | likely benign |
| rs766972215 | 16:29,859,188 | G/C | — | uncertain significance |
| rs143008418 | 16:29,859,219 | G/A | — | uncertain significance |
| rs142001681 | 16:29,859,282 | A/G | — | benign |
| rs34437030 | 16:29,859,305 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.