MX1
MX dynamin like GTPase 1
Summary
This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Known Variants49 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs459482 | 21:42,793,791 | C/G | 5 prime UTR variant | — |
| rs17000900 | 21:42,798,030 | C/T | — | — |
| rs2071430 | 21:42,798,065 | G/T | regulatory region variant | — |
| rs464138 | 21:42,798,173 | A/C | regulatory region variant | — |
| rs7280422 | 21:42,801,567 | C/T | — | — |
| rs147615997 | 21:42,804,019 | A/G | — | uncertain significance |
| rs778536407 | 21:42,804,074 | C/A | — | uncertain significance |
| rs368699729 | 21:42,804,088 | A/G | — | uncertain significance |
| rs139452684 | 21:42,804,111 | C/G | — | benign |
| rs1008139418 | 21:42,807,789 | A/G | — | uncertain significance |
| rs138644617 | 21:42,807,807 | G/A | — | uncertain significance |
| rs545554440 | 21:42,807,877 | C/G | — | uncertain significance |
| rs768751466 | 21:42,807,878 | G/A | — | uncertain significance |
| rs149433993 | 21:42,807,955 | C/A | — | uncertain significance |
| rs17000915 | 21:42,809,045 | G/A | — | benign |
| rs2516949586 | 21:42,811,632 | A/G | — | uncertain significance |
| rs142294097 | 21:42,811,638 | G/A | — | uncertain significance |
| rs201089600 | 21:42,811,732 | C/T | — | uncertain significance |
| rs758721832 | 21:42,813,698 | C/G | — | uncertain significance |
| rs145851733 | 21:42,813,706 | G/A | — | uncertain significance |
| rs752288246 | 21:42,813,763 | A/G | — | uncertain significance |
| rs2090525043 | 21:42,813,787 | T/G | — | uncertain significance |
| rs770523779 | 21:42,813,820 | T/C | — | uncertain significance |
| rs761404175 | 21:42,815,723 | T/C | — | uncertain significance |
| rs764607038 | 21:42,815,727 | G/A | — | likely benign |
| rs62623435 | 21:42,815,731 | G/A | — | likely benign |
| rs376136763 | 21:42,815,741 | C/T | — | uncertain significance |
| rs778153448 | 21:42,815,750 | G/A | — | uncertain significance |
| rs115187240 | 21:42,817,431 | G/A | — | benign |
| rs139733063 | 21:42,817,453 | G/A | — | uncertain significance |
| rs34717738 | 21:42,817,937 | C/A | — | uncertain significance |
| rs1029380475 | 21:42,818,013 | A/C | — | uncertain significance |
| rs1388523870 | 21:42,821,097 | T/A | — | uncertain significance |
| rs2517027448 | 21:42,821,103 | A/G | — | uncertain significance |
| rs375670151 | 21:42,821,112 | G/A | — | uncertain significance |
| rs767071134 | 21:42,821,193 | C/T | — | uncertain significance |
| rs149908360 | 21:42,823,102 | C/T | — | uncertain significance |
| rs1330751243 | 21:42,824,684 | A/C | — | uncertain significance |
| rs2090866244 | 21:42,824,693 | A/G | — | uncertain significance |
| rs117998041 | 21:42,824,730 | C/T | — | likely benign |
| rs201649510 | 21:42,824,741 | C/T | — | uncertain significance |
| rs755400827 | 21:42,824,771 | T/C | — | uncertain significance |
| rs140570072 | 21:42,830,468 | G/A | — | uncertain significance |
| rs375454579 | 21:42,830,516 | C/G | — | uncertain significance |
| rs148464043 | 21:42,830,597 | G/C | — | benign |
| rs372998034 | 21:42,830,599 | G/A | — | uncertain significance |
| rs142550630 | 21:42,830,615 | G/A | — | uncertain significance |
| rs1345167441 | 21:42,830,662 | C/T | — | uncertain significance |
| rs142831212 | 21:42,830,716 | T/C | — | benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.