MX1

MX dynamin like GTPase 1

Summary

This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Known Variants49 total

rsidPosition (GRCh37)AllelesClassClinVar
rs45948221:42,793,791C/G5 prime UTR variant
rs1700090021:42,798,030C/T
rs207143021:42,798,065G/Tregulatory region variant
rs46413821:42,798,173A/Cregulatory region variant
rs728042221:42,801,567C/T
rs14761599721:42,804,019A/Guncertain significance
rs77853640721:42,804,074C/Auncertain significance
rs36869972921:42,804,088A/Guncertain significance
rs13945268421:42,804,111C/Gbenign
rs100813941821:42,807,789A/Guncertain significance
rs13864461721:42,807,807G/Auncertain significance
rs54555444021:42,807,877C/Guncertain significance
rs76875146621:42,807,878G/Auncertain significance
rs14943399321:42,807,955C/Auncertain significance
rs1700091521:42,809,045G/Abenign
rs251694958621:42,811,632A/Guncertain significance
rs14229409721:42,811,638G/Auncertain significance
rs20108960021:42,811,732C/Tuncertain significance
rs75872183221:42,813,698C/Guncertain significance
rs14585173321:42,813,706G/Auncertain significance
rs75228824621:42,813,763A/Guncertain significance
rs209052504321:42,813,787T/Guncertain significance
rs77052377921:42,813,820T/Cuncertain significance
rs76140417521:42,815,723T/Cuncertain significance
rs76460703821:42,815,727G/Alikely benign
rs6262343521:42,815,731G/Alikely benign
rs37613676321:42,815,741C/Tuncertain significance
rs77815344821:42,815,750G/Auncertain significance
rs11518724021:42,817,431G/Abenign
rs13973306321:42,817,453G/Auncertain significance
rs3471773821:42,817,937C/Auncertain significance
rs102938047521:42,818,013A/Cuncertain significance
rs138852387021:42,821,097T/Auncertain significance
rs251702744821:42,821,103A/Guncertain significance
rs37567015121:42,821,112G/Auncertain significance
rs76707113421:42,821,193C/Tuncertain significance
rs14990836021:42,823,102C/Tuncertain significance
rs133075124321:42,824,684A/Cuncertain significance
rs209086624421:42,824,693A/Guncertain significance
rs11799804121:42,824,730C/Tlikely benign
rs20164951021:42,824,741C/Tuncertain significance
rs75540082721:42,824,771T/Cuncertain significance
rs14057007221:42,830,468G/Auncertain significance
rs37545457921:42,830,516C/Guncertain significance
rs14846404321:42,830,597G/Cbenign
rs37299803421:42,830,599G/Auncertain significance
rs14255063021:42,830,615G/Auncertain significance
rs134516744121:42,830,662C/Tuncertain significance
rs14283121221:42,830,716T/Cbenign

Gene information from NCBI Gene. Variant classifications from ClinVar.