MYB
MYB proto-oncogene, transcription factor
Summary
This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Known Variants50 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2128277525 | 6:135,502,663 | A/C | — | uncertain significance |
| rs187487616 | 6:135,511,259 | C/T | splice region variant | Likely benign |
| rs777044345 | 6:135,511,288 | C/T | — | likely benign |
| rs79564755 | 6:135,512,779 | A/G | regulatory region variant | — |
| rs2482446206 | 6:135,513,467 | A/G | — | uncertain significance |
| rs950607758 | 6:135,513,581 | A/G | — | uncertain significance |
| rs61756670 | 6:135,513,684 | T/C | — | benign |
| rs769759766 | 6:135,515,045 | G/A | — | uncertain significance |
| rs114577782 | 6:135,515,565 | C/T | — | benign |
| rs1777214956 | 6:135,516,903 | C/G | — | uncertain significance |
| rs2229999 | 6:135,516,944 | C/T | — | benign |
| rs189282361 | 6:135,517,020 | T/G | — | likely benign |
| rs6927965 | 6:135,517,059 | C/T | — | benign |
| rs12663543 | 6:135,517,614 | A/G | upstream gene variant | — |
| rs73555742 | 6:135,518,108 | T/C | — | benign |
| rs770846525 | 6:135,518,137 | C/A | — | uncertain significance |
| rs1284308056 | 6:135,518,198 | C/A | — | uncertain significance |
| rs775518429 | 6:135,518,260 | G/A | — | uncertain significance |
| rs1299405263 | 6:135,518,367 | C/A | — | uncertain significance |
| rs2482543612 | 6:135,518,390 | A/C | — | likely benign |
| rs1391566299 | 6:135,520,073 | A/G | — | uncertain significance |
| rs763451124 | 6:135,520,094 | T/C | — | uncertain significance |
| rs2230000 | 6:135,520,107 | C/A | — | benign |
| rs377014519 | 6:135,520,110 | C/A | — | uncertain significance |
| rs756037127 | 6:135,520,112 | C/G | — | uncertain significance |
| rs143010463 | 6:135,520,156 | C/A | — | uncertain significance |
| rs2482572151 | 6:135,520,184 | A/G | — | uncertain significance |
| rs779796852 | 6:135,521,239 | A/G | — | uncertain significance |
| rs1415546608 | 6:135,521,269 | A/G | — | uncertain significance |
| rs34119110 | 6:135,521,280 | A/G | — | likely benign |
| rs75521209 | 6:135,521,289 | A/G | — | benign |
| rs1042484593 | 6:135,521,291 | A/G | — | uncertain significance |
| rs900245440 | 6:135,521,332 | A/T | — | uncertain significance |
| rs17064293 | 6:135,521,422 | G/T | — | benign |
| rs73555746 | 6:135,521,489 | A/C | — | likely benign |
| rs113182184 | 6:135,521,495 | G/A | — | likely benign |
| rs79688604 | 6:135,521,505 | T/C | — | benign |
| rs758697644 | 6:135,521,540 | A/G | — | uncertain significance |
| rs1272659280 | 6:135,522,857 | C/A | — | uncertain significance |
| rs370301077 | 6:135,524,391 | T/A | — | uncertain significance |
| rs114303912 | 6:135,524,414 | C/T | — | likely benign |
| rs10457633 | 6:135,529,211 | T/A | intron variant | — |
| rs210950 | 6:135,531,451 | C/A | — | — |
| rs563143880 | 6:135,535,782 | A/G | — | — |
| rs210939 | 6:135,537,890 | C/G | intron variant | — |
| rs61753805 | 6:135,539,033 | G/A | — | uncertain significance |
| rs758101576 | 6:135,539,059 | T/C | — | uncertain significance |
| rs751072359 | 6:135,539,066 | G/C | — | uncertain significance |
| rs35664708 | 6:135,539,103 | A/G | — | benign |
| rs210937 | 6:135,540,380 | G/A | downstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.