MYH16
myosin heavy chain 16
Summary
The protein coding status of the MYH16 gene is uncertain. In nonhuman primates, this gene encodes a sarcomeric myosin heavy chain expressed in masticatory muscles, but has been hypothesized to be inactivated in humans. Stedman et al. (2004) [PubMed 15042088] suggest that the decrement in masticatory muscle size caused by the inactivation of MYH16 removed an evolutionary constraint on encephalization in early man. However, there is peptide support suggesting that a shorter protein containing only a myosin tail domain is expressed in human. [provided by RefSeq, Jul 2024]
Known Variants6 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs12535654 | 7:98,858,784 | G/A | intron variant | — |
| rs111643567 | 7:98,861,216 | G/A | — | — |
| rs11971111 | 7:98,881,654 | G/A | intron variant | — |
| rs143938602 | 7:98,892,524 | G/T | intron variant | — |
| rs10267346 | 7:98,898,767 | T/A | — | — |
| rs138945337 | 7:98,904,065 | G/T | intron variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.