NCK2
NCK adaptor protein 2
Summary
This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Known Variants18 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs11692954 | 2:106,372,542 | T/C | — | — |
| rs12052297 | 2:106,381,060 | A/T | — | — |
| rs6707820 | 2:106,425,713 | C/T | regulatory region variant | — |
| rs12997003 | 2:106,436,413 | C/T | intron variant | — |
| rs2377339 | 2:106,457,291 | A/G | intron variant | — |
| rs2467152920 | 2:106,471,583 | G/A | — | uncertain significance |
| rs776872198 | 2:106,497,841 | C/T | — | uncertain significance |
| rs2104659855 | 2:106,497,846 | G/A | — | uncertain significance |
| rs767425900 | 2:106,497,869 | C/A | — | uncertain significance |
| rs753586078 | 2:106,497,889 | A/T | — | uncertain significance |
| rs1678485517 | 2:106,498,017 | A/T | — | uncertain significance |
| rs755385208 | 2:106,498,113 | G/T | — | uncertain significance |
| rs2467265273 | 2:106,498,243 | A/C | — | uncertain significance |
| rs751867472 | 2:106,498,303 | A/G | — | uncertain significance |
| rs1678509230 | 2:106,498,324 | G/A | — | uncertain significance |
| rs1678516490 | 2:106,498,389 | G/A | — | uncertain significance |
| rs2033008 | 2:106,502,585 | T/A | regulatory region variant | — |
| rs62148194 | 2:106,510,184 | C/T | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.