NCKAP1

NCK associated protein 1

Summary

Contributes to small GTPase binding activity. Involved in Rac protein signal transduction; positive regulation of Arp2/3 complex-mediated actin nucleation; and positive regulation of lamellipodium assembly. Located in extracellular exosome and focal adhesion. Part of SCAR complex. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants92 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs368498921	2:183,790,443	G/A	—	uncertain significance
rs1249597061	2:183,790,471	A/T	—	uncertain significance
rs2468533857	2:183,790,537	C/A	—	likely pathogenic
rs2468535704	2:183,791,617	A/T	—	uncertain significance
rs761671233	2:183,792,845	C/T	—	uncertain significance
rs1233796354	2:183,792,863	A/G	—	likely benign
rs376392398	2:183,792,864	C/T	—	uncertain significance
rs1362165435	2:183,792,944	G/T	—	uncertain significance
rs2468543438	2:183,795,482	G/A	—	uncertain significance
rs138921784	2:183,795,493	T/C	—	likely benign
rs1342338398	2:183,795,511	T/C	—	likely benign
rs1418757580	2:183,799,523	A/T	—	uncertain significance
rs144468405	2:183,799,524	T/C	—	likely benign
rs9288088	2:183,799,558	G/C	—	benign
rs2468551976	2:183,800,032	C/T	—	uncertain significance
rs144374101	2:183,800,060	A/G	—	likely benign
rs1696852836	2:183,800,097	T/C	—	uncertain significance
rs2105804821	2:183,800,101	C/T	—	uncertain significance
rs1453708891	2:183,806,894	A/T	—	uncertain significance
rs1476633029	2:183,817,547	T/C	—	uncertain significance
rs750663916	2:183,817,586	G/C	—	uncertain significance
rs2468587450	2:183,817,845	T/C	—	uncertain significance
rs2468587558	2:183,817,883	T/C	—	uncertain significance
rs1697253653	2:183,817,893	G/T	—	uncertain significance
rs2468587603	2:183,817,905	G/A	—	uncertain significance
rs2468587659	2:183,817,914	T/C	—	uncertain significance
rs2468587724	2:183,817,940	T/C	—	uncertain significance
rs2468587730	2:183,817,944	C/T	—	uncertain significance
rs2468587835	2:183,817,977	A/G	—	uncertain significance
rs2105823042	2:183,817,987	A/C	—	likely pathogenic
rs1199386055	2:183,817,988	C/G	—	uncertain significance
rs1697256636	2:183,818,018	T/G	—	uncertain significance
rs2105823081	2:183,818,022	G/A	—	likely pathogenic
rs538891750	2:183,821,230	G/A	—	pathogenic
rs1697331420	2:183,821,271	T/C	—	uncertain significance
rs2468593331	2:183,821,274	T/C	—	uncertain significance
rs771473358	2:183,821,278	T/C	—	uncertain significance
rs2105826542	2:183,821,295	G/A	—	uncertain significance
rs1204048577	2:183,821,297	A/C	—	likely benign
rs200328412	2:183,821,309	C/A	—	uncertain significance
rs2468595292	2:183,822,211	C/G	—	uncertain significance
rs2468595296	2:183,822,212	A/G	—	uncertain significance
rs1482735707	2:183,822,265	C/A	—	uncertain significance
rs148451124	2:183,826,892	C/A	—	uncertain significance
rs2468604532	2:183,826,907	G/A	—	pathogenic
rs770004612	2:183,826,908	T/C	—	likely benign
rs930006120	2:183,826,985	T/A	—	uncertain significance
rs2271671	2:183,827,018	G/A	—	benign
rs2468609506	2:183,829,532	A/T	—	uncertain significance
rs2468631678	2:183,841,645	C/A	—	uncertain significance
rs750171376	2:183,846,022	C/G	—	uncertain significance
rs2468640605	2:183,846,117	T/C	—	uncertain significance
rs2468643097	2:183,847,583	T/G	—	uncertain significance
rs2468644197	2:183,848,030	C/G	—	likely benign
rs2105855002	2:183,848,037	G/C	—	uncertain significance
rs35142583	2:183,848,053	A/G	—	benign
rs1014714814	2:183,848,083	C/T	—	likely benign
rs1400130	2:183,848,114	T/C	—	benign
rs572926015	2:183,850,924	A/G	—	uncertain significance
rs2468650275	2:183,850,927	C/T	—	uncertain significance
rs544476041	2:183,850,933	T/C	—	uncertain significance
rs2105858704	2:183,850,961	T/G	—	benign
rs1431553137	2:183,850,962	G/A	—	likely benign
rs2468656006	2:183,853,780	C/T	—	uncertain significance
rs533081641	2:183,853,824	G/A	—	uncertain significance
rs550349550	2:183,853,881	G/A	—	uncertain significance
rs920794438	2:183,853,890	A/C	—	uncertain significance
rs760956582	2:183,853,896	T/C	—	uncertain significance
rs1397377162	2:183,853,901	C/G	—	uncertain significance
rs2468666450	2:183,859,579	T/A	—	likely pathogenic
rs2468666563	2:183,859,612	G/A	—	uncertain significance
rs1191239285	2:183,860,455	T/A	—	uncertain significance
rs1484844979	2:183,860,460	C/T	—	uncertain significance
rs2105869050	2:183,860,541	A/G	—	uncertain significance
rs1229304462	2:183,866,688	T/C	—	uncertain significance
rs2468680609	2:183,866,695	C/G	—	uncertain significance
rs141846108	2:183,866,702	T/C	—	likely benign
rs148713736	2:183,866,756	T/C	—	likely benign
rs779215853	2:183,866,906	T/C	—	uncertain significance
rs1698401811	2:183,867,707	C/T	—	uncertain significance
rs759179119	2:183,867,721	C/A	—	uncertain significance
rs2105876212	2:183,867,754	T/C	—	uncertain significance
rs2468723128	2:183,888,605	C/T	—	uncertain significance
rs2468725144	2:183,889,720	C/T	—	uncertain significance
rs772657713	2:183,889,735	T/C	—	uncertain significance
rs75602566	2:183,902,403	C/A	regulatory region variant	—
rs2468325972	2:183,902,731	T/G	—	uncertain significance
rs2468326017	2:183,902,740	G/A	—	uncertain significance
rs2468326140	2:183,902,767	T/G	—	uncertain significance
rs138660373	2:183,902,768	G/A	—	likely benign
rs1184593257	2:183,902,784	T/C	—	uncertain significance
rs28429165	2:183,903,211	G/A	regulatory region variant	—

Gene information from NCBI Gene. Variant classifications from ClinVar.