NCOA4
nuclear receptor coactivator 4
Summary
This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009]
Known Variants34 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs10761581 | 10:51,568,378 | T/G | missense variant | — |
| rs10740051 | 10:51,570,152 | G/A | intron variant | — |
| rs1554923306 | 10:51,579,180 | T/G | — | uncertain significance |
| rs2496399099 | 10:51,580,582 | A/G | — | uncertain significance |
| rs782517064 | 10:51,580,695 | C/T | — | uncertain significance |
| rs782298209 | 10:51,582,808 | G/C | — | uncertain significance |
| rs781847458 | 10:51,582,857 | C/T | — | uncertain significance |
| rs113955117 | 10:51,582,911 | C/T | — | likely benign |
| rs117257055 | 10:51,584,644 | A/G | — | benign |
| rs373872053 | 10:51,584,652 | G/A | — | uncertain significance |
| rs2496348662 | 10:51,584,721 | A/G | — | uncertain significance |
| rs2496348525 | 10:51,584,734 | C/T | — | uncertain significance |
| rs113590757 | 10:51,584,794 | A/T | missense variant | — |
| rs148951318 | 10:51,584,844 | C/T | — | uncertain significance |
| rs368269770 | 10:51,584,869 | A/C | — | uncertain significance |
| rs561516928 | 10:51,584,947 | A/G | — | uncertain significance |
| rs1334509523 | 10:51,584,970 | G/A | — | uncertain significance |
| rs782034010 | 10:51,585,121 | A/G | — | uncertain significance |
| rs141175678 | 10:51,585,132 | A/G | — | uncertain significance |
| rs112613721 | 10:51,585,161 | G/A | — | likely benign |
| rs367823699 | 10:51,585,184 | A/G | — | likely benign |
| rs200611408 | 10:51,585,211 | A/C | — | uncertain significance |
| rs146205784 | 10:51,585,223 | G/A | — | benign |
| rs61754798 | 10:51,585,241 | A/G | — | not provided |
| rs142507073 | 10:51,585,348 | G/A | — | benign |
| rs142672975 | 10:51,585,385 | C/T | — | benign |
| rs79761167 | 10:51,585,425 | C/G | — | benign |
| rs2496341614 | 10:51,585,426 | A/G | — | uncertain significance |
| rs1363026440 | 10:51,585,438 | G/A | — | likely benign |
| rs782500132 | 10:51,586,305 | A/G | — | likely benign |
| rs2496330803 | 10:51,586,395 | A/G | — | uncertain significance |
| rs553213400 | 10:51,586,398 | G/A | — | uncertain significance |
| rs1183208806 | 10:51,586,643 | G/A | — | uncertain significance |
| rs74877435 | 10:51,588,890 | G/A | downstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.