NEIL3
nei like DNA glycosylase 3
Summary
NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).[supplied by OMIM, Mar 2008]
Known Variants41 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs529938245 | 4:178,231,136 | A/C | — | uncertain significance |
| rs10013040 | 4:178,231,152 | C/A | synonymous variant | benign |
| rs375478163 | 4:178,231,164 | C/T | — | likely benign |
| rs141063624 | 4:178,231,176 | G/A | — | likely benign |
| rs767730991 | 4:178,231,198 | G/T | — | uncertain significance |
| rs758245844 | 4:178,231,222 | G/A | — | uncertain significance |
| rs1734448457 | 4:178,231,252 | G/T | — | uncertain significance |
| rs1338708417 | 4:178,243,698 | A/G | — | uncertain significance |
| rs148027965 | 4:178,243,716 | T/G | — | uncertain significance |
| rs1474425066 | 4:178,243,722 | C/A | — | uncertain significance |
| rs2477656762 | 4:178,243,732 | A/C | — | likely benign |
| rs146027968 | 4:178,256,871 | T/A | — | uncertain significance |
| rs199732227 | 4:178,256,906 | G/A | — | uncertain significance |
| rs7689099 | 4:178,256,913 | C/G | — | benign |
| rs114922382 | 4:178,256,920 | G/C | — | likely benign |
| rs1734966027 | 4:178,256,947 | T/G | — | uncertain significance |
| rs142427084 | 4:178,257,467 | G/A | — | uncertain significance |
| rs2271102 | 4:178,257,516 | G/A | — | benign |
| rs12645561 | 4:178,260,872 | C/T | downstream gene variant | benign |
| rs2477684323 | 4:178,260,961 | A/G | — | uncertain significance |
| rs17676249 | 4:178,262,683 | C/T | — | benign |
| rs28618113 | 4:178,262,811 | T/C | — | benign |
| rs141868607 | 4:178,272,607 | C/T | — | uncertain significance |
| rs1054753 | 4:178,272,748 | A/G | — | benign |
| rs2048074 | 4:178,274,565 | A/G | synonymous variant | benign |
| rs1308309925 | 4:178,274,572 | G/C | — | uncertain significance |
| rs1407072211 | 4:178,274,680 | C/T | — | uncertain significance |
| rs10007075 | 4:178,274,694 | G/T | — | benign |
| rs570909293 | 4:178,274,727 | G/C | — | uncertain significance |
| rs13112358 | 4:178,274,750 | C/T | missense variant | benign |
| rs1255702136 | 4:178,274,776 | A/G | — | uncertain significance |
| rs768133212 | 4:178,274,821 | C/A | — | uncertain significance |
| rs13112390 | 4:178,274,835 | A/C | missense variant | benign |
| rs2477720393 | 4:178,274,852 | T/C | — | uncertain significance |
| rs375105298 | 4:178,281,668 | T/C | — | uncertain significance |
| rs746254453 | 4:178,281,680 | A/G | — | uncertain significance |
| rs370522024 | 4:178,281,715 | T/A | — | uncertain significance |
| rs1876268 | 4:178,281,754 | G/A | — | benign |
| rs36005630 | 4:178,283,446 | G/T | — | likely benign |
| rs147490321 | 4:178,283,548 | C/G | — | uncertain significance |
| rs771744474 | 4:178,283,584 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.