NEK8

NIMA related kinase 8

Summary

This gene encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in the related mouse gene are associated with a disease phenotype that closely parallels the juvenile autosomal recessive form of polycystic kidney disease in humans. [provided by RefSeq, Jul 2008]

Known Variants284 total

rsidPosition (GRCh37)AllelesClassClinVar
rs75947487017:27,055,840G/A—likely benign
rs19962135417:27,055,853C/G—uncertain significance
rs76906187417:27,055,854G/A—uncertain significance
rs254443205117:27,055,868G/A—uncertain significance
rs76605031217:27,055,872C/T—uncertain significance
rs254443206517:27,055,875T/C—uncertain significance
rs136726867717:27,055,879G/A—pathogenic
rs75690509517:27,055,895G/A—likely benign
rs77630472517:27,055,898G/T—likely benign
rs721121417:27,056,025C/A—benign
rs721122017:27,056,026C/T—benign
rs5746624317:27,059,666T/C——
rs76905808817:27,060,991G/A—conflicting classifications of pathogenicity
rs74843051317:27,061,010C/T—conflicting classifications of pathogenicity
rs254443689617:27,061,012T/C—uncertain significance
rs254443691417:27,061,024A/T—uncertain significance
rs203433628517:27,061,044A/G—uncertain significance
rs254443697017:27,061,080G/A—uncertain significance
rs20221731017:27,061,084A/T—uncertain significance
rs156775913017:27,061,086C/T—conflicting classifications of pathogenicity
rs156775913217:27,061,092G/T—uncertain significance
rs254443698817:27,061,095G/C—uncertain significance
rs215173153117:27,061,098C/G—uncertain significance
rs136791753317:27,061,138A/G—uncertain significance
rs203433729417:27,061,139T/A—uncertain significance
rs254443705517:27,061,149T/G—uncertain significance
rs77926503317:27,061,151C/T—likely benign
rs119965922017:27,061,178C/T—likely benign
rs19998415217:27,061,187C/T—likely benign
rs76945556817:27,061,201C/T—uncertain significance
rs142645128517:27,061,213C/T—likely benign
rs77414485117:27,061,217C/T—likely benign
rs1772082617:27,061,271A/G—benign
rs991108617:27,061,586C/T—benign
rs54695769517:27,061,631G/A—benign
rs76647887017:27,061,778C/T—likely benign
rs75499742717:27,061,791C/T—likely benign
rs155556378717:27,061,795A/G—pathogenic
rs77911382117:27,061,805A/G—uncertain significance
rs74740162417:27,061,820G/A—uncertain significance
rs18720885017:27,061,822T/C—likely benign
rs138118963517:27,061,823G/T—uncertain significance
rs14025507717:27,061,830C/G—conflicting classifications of pathogenicity
rs74903039817:27,061,836G/A—uncertain significance
rs77391823317:27,061,848C/A—likely benign
rs76178736317:27,061,849A/G—uncertain significance
rs77215799517:27,061,852C/T—likely benign
rs88656627417:27,061,864G/A—uncertain significance
rs155556382117:27,061,875G/C—likely benign
rs75279278217:27,061,915C/Tstop gainedpathogenic
rs20120231817:27,061,921C/T—likely benign
rs14159933017:27,061,955G/T—uncertain significance
rs77175536517:27,061,963G/A—uncertain significance
rs77326721217:27,061,971C/T—likely benign
rs77056453217:27,061,973G/T—uncertain significance
rs77649561817:27,061,980C/T—likely benign
rs203434848717:27,061,989C/T—uncertain significance
rs203434879017:27,062,014G/T—uncertain significance
rs119443900617:27,062,033A/G—likely benign
rs75082171117:27,062,039G/T—likely benign
rs37073274917:27,062,249A/G—likely benign
rs203435228717:27,062,277A/G—uncertain significance
rs254443882817:27,062,279A/T—uncertain significance
rs215173202217:27,062,307C/G—uncertain significance
rs75648615517:27,062,350C/T—likely benign
rs106050139917:27,062,352A/C—uncertain significance
rs20177396517:27,062,353C/T—conflicting classifications of pathogenicity
rs75233137217:27,062,354G/A—uncertain significance
rs75623124817:27,062,360G/Cmissense variant—
rs203435312017:27,062,373G/C—uncertain significance
rs55550187017:27,062,380C/T—likely benign
rs77877082617:27,062,389G/A—likely pathogenic
rs254443901917:27,062,398A/G—uncertain significance
rs1164995717:27,062,401C/T—conflicting classifications of pathogenicity
rs15111132117:27,064,286C/T—likely benign
rs254444075717:27,064,329G/A—likely benign
rs77977715317:27,064,355G/C—uncertain significance
rs74911356017:27,064,359C/T—likely benign
rs159780644117:27,064,361C/A—uncertain significance
rs76848211517:27,064,371T/C—uncertain significance
rs96565285517:27,064,372A/G—uncertain significance
rs140376672817:27,064,378G/C—uncertain significance
rs77917568117:27,064,381C/T—uncertain significance
rs36880285217:27,064,442G/A—conflicting classifications of pathogenicity
rs77731418517:27,064,449A/G—likely benign
rs76557488117:27,064,455C/T—likely benign
rs90160972317:27,064,472C/G—uncertain significance
rs76137854717:27,064,473C/G—likely benign
rs74992698717:27,064,483C/T—uncertain significance
rs6174500317:27,064,484G/A—uncertain significance
rs75475661517:27,064,506C/T—uncertain significance
rs15003220317:27,064,507G/A—uncertain significance
rs74834186117:27,064,509C/T—likely benign
rs146309481917:27,064,512G/C—likely benign
rs37167380417:27,064,522C/T—uncertain significance
rs74705134617:27,064,523G/A—uncertain significance
rs74644651317:27,064,529G/A—uncertain significance
rs37166840417:27,064,550G/A—likely benign
rs37502166817:27,064,552G/A—likely benign
rs124456250617:27,064,689G/T—likely benign

Showing 100 of 284 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.