NLRP10
NLR family pyrin domain containing 10
Summary
Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. [provided by RefSeq, Jul 2008]
Known Variants47 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1438946469 | 11:7,981,211 | G/A | — | uncertain significance |
| rs2495377046 | 11:7,981,253 | T/C | — | uncertain significance |
| rs199475856 | 11:7,981,272 | A/G | — | not provided |
| rs112855729 | 11:7,981,323 | A/T | — | benign |
| rs868150302 | 11:7,981,511 | C/T | — | uncertain significance |
| rs141049984 | 11:7,981,558 | C/G | — | uncertain significance |
| rs1002791594 | 11:7,981,580 | A/C | — | uncertain significance |
| rs144948801 | 11:7,981,590 | T/A | — | uncertain significance |
| rs779742470 | 11:7,981,637 | C/T | — | uncertain significance |
| rs202121901 | 11:7,981,640 | T/C | — | uncertain significance |
| rs199475855 | 11:7,981,749 | C/T | — | not provided |
| rs371421931 | 11:7,981,751 | G/C | — | uncertain significance |
| rs760727623 | 11:7,981,778 | A/G | — | uncertain significance |
| rs376883095 | 11:7,981,793 | G/A | — | uncertain significance |
| rs1941690958 | 11:7,981,808 | C/T | — | uncertain significance |
| rs1372068484 | 11:7,981,871 | C/T | — | uncertain significance |
| rs759478163 | 11:7,981,948 | A/C | — | uncertain significance |
| rs1355744078 | 11:7,981,991 | A/G | — | uncertain significance |
| rs1156422466 | 11:7,982,107 | C/T | — | uncertain significance |
| rs1381182659 | 11:7,982,120 | G/C | — | uncertain significance |
| rs199475854 | 11:7,982,166 | C/T | — | not provided |
| rs150634549 | 11:7,982,225 | T/G | — | uncertain significance |
| rs73412948 | 11:7,982,298 | G/A | — | benign |
| rs1251292502 | 11:7,982,300 | A/G | — | uncertain significance |
| rs1485106735 | 11:7,982,315 | T/C | — | uncertain significance |
| rs781429654 | 11:7,982,339 | G/T | — | uncertain significance |
| rs143710587 | 11:7,982,350 | T/C | — | uncertain significance |
| rs112117055 | 11:7,982,367 | C/T | — | benign |
| rs59039403 | 11:7,982,432 | G/T | synonymous variant | — |
| rs768485827 | 11:7,982,477 | C/T | — | uncertain significance |
| rs202157379 | 11:7,982,498 | G/T | — | uncertain significance |
| rs529453927 | 11:7,982,612 | C/T | — | uncertain significance |
| rs1344462295 | 11:7,982,686 | G/A | — | uncertain significance |
| rs1278048406 | 11:7,982,851 | C/A | — | uncertain significance |
| rs199476232 | 11:7,984,713 | C/A | — | not provided |
| rs765282017 | 11:7,984,768 | T/C | — | uncertain significance |
| rs2495392707 | 11:7,984,771 | C/T | — | uncertain significance |
| rs748295340 | 11:7,984,801 | A/G | — | uncertain significance |
| rs527498709 | 11:7,984,820 | G/A | — | uncertain significance |
| rs199475853 | 11:7,984,826 | C/T | — | not provided |
| rs765060448 | 11:7,984,859 | T/C | — | uncertain significance |
| rs759378060 | 11:7,984,945 | C/T | — | uncertain significance |
| rs1051203336 | 11:7,984,967 | T/C | — | uncertain significance |
| rs535251598 | 11:7,985,015 | G/A | — | uncertain significance |
| rs759502711 | 11:7,985,032 | G/C | — | uncertain significance |
| rs199475852 | 11:7,985,346 | C/T | — | not provided |
| rs199475851 | 11:7,985,494 | A/C | — | not provided |
Gene information from NCBI Gene. Variant classifications from ClinVar.