NME4

NME/NM23 nucleoside diphosphate kinase 4

Summary

The nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. The enzymes are products of the nm23 gene family, which includes NME4 (Milon et al., 1997 [PubMed 9099850]).[supplied by OMIM, May 2008]

Known Variants25 total

rsidPosition (GRCh37)AllelesClassClinVar
rs19298167916:447,104G/Aregulatory region variant
rs205455992316:447,230G/Tuncertain significance
rs98406290416:447,256G/Tuncertain significance
rs126059875416:447,265T/Cuncertain significance
rs254861954316:447,269G/Tuncertain significance
rs121185231616:447,272C/Guncertain significance
rs159718073416:447,286C/Tuncertain significance
rs74814925616:449,007C/Tuncertain significance
rs37257349716:449,037G/Auncertain significance
rs77854734416:449,052C/Tuncertain significance
rs74675310916:449,058G/Auncertain significance
rs11707832316:449,089G/Auncertain significance
rs205460628916:449,118C/Guncertain significance
rs37288745416:449,391G/Alikely benign
rs14814491116:449,399C/Tbenign
rs14362383316:449,442C/Guncertain significance
rs122428306416:449,456G/Auncertain significance
rs207191416:449,554G/Cbenign
rs74538860816:449,639T/Auncertain significance
rs20119468716:449,652G/Auncertain significance
rs13857679516:449,685C/Tuncertain significance
rs57122071216:450,232G/Auncertain significance
rs11276265116:450,259C/Tuncertain significance
rs55559418016:450,287G/Auncertain significance
rs76356020016:450,310G/Auncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.