NME4
NME/NM23 nucleoside diphosphate kinase 4
Summary
The nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. The enzymes are products of the nm23 gene family, which includes NME4 (Milon et al., 1997 [PubMed 9099850]).[supplied by OMIM, May 2008]
Known Variants25 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs192981679 | 16:447,104 | G/A | regulatory region variant | — |
| rs2054559923 | 16:447,230 | G/T | — | uncertain significance |
| rs984062904 | 16:447,256 | G/T | — | uncertain significance |
| rs1260598754 | 16:447,265 | T/C | — | uncertain significance |
| rs2548619543 | 16:447,269 | G/T | — | uncertain significance |
| rs1211852316 | 16:447,272 | C/G | — | uncertain significance |
| rs1597180734 | 16:447,286 | C/T | — | uncertain significance |
| rs748149256 | 16:449,007 | C/T | — | uncertain significance |
| rs372573497 | 16:449,037 | G/A | — | uncertain significance |
| rs778547344 | 16:449,052 | C/T | — | uncertain significance |
| rs746753109 | 16:449,058 | G/A | — | uncertain significance |
| rs117078323 | 16:449,089 | G/A | — | uncertain significance |
| rs2054606289 | 16:449,118 | C/G | — | uncertain significance |
| rs372887454 | 16:449,391 | G/A | — | likely benign |
| rs148144911 | 16:449,399 | C/T | — | benign |
| rs143623833 | 16:449,442 | C/G | — | uncertain significance |
| rs1224283064 | 16:449,456 | G/A | — | uncertain significance |
| rs2071914 | 16:449,554 | G/C | — | benign |
| rs745388608 | 16:449,639 | T/A | — | uncertain significance |
| rs201194687 | 16:449,652 | G/A | — | uncertain significance |
| rs138576795 | 16:449,685 | C/T | — | uncertain significance |
| rs571220712 | 16:450,232 | G/A | — | uncertain significance |
| rs112762651 | 16:450,259 | C/T | — | uncertain significance |
| rs555594180 | 16:450,287 | G/A | — | uncertain significance |
| rs763560200 | 16:450,310 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.