NMI
N-myc and STAT interactor
Summary
NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias. [provided by RefSeq, Jul 2008]
Known Variants23 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs142057911 | 2:152,127,215 | C/T | — | uncertain significance |
| rs150664393 | 2:152,127,219 | G/T | — | not provided |
| rs1683167396 | 2:152,127,230 | G/A | — | likely benign |
| rs2467666699 | 2:152,127,239 | C/G | — | uncertain significance |
| rs754210759 | 2:152,127,250 | T/C | — | uncertain significance |
| rs773751305 | 2:152,128,204 | A/T | — | uncertain significance |
| rs57201382 | 2:152,131,543 | C/T | intron variant | — |
| rs2467675005 | 2:152,132,000 | C/G | — | uncertain significance |
| rs199573903 | 2:152,132,015 | G/A | — | uncertain significance |
| rs372268328 | 2:152,132,052 | C/T | — | uncertain significance |
| rs200999974 | 2:152,132,055 | G/A | — | likely benign |
| rs535520274 | 2:152,132,076 | T/C | — | uncertain significance |
| rs201563970 | 2:152,132,078 | C/T | — | uncertain significance |
| rs897214816 | 2:152,132,152 | A/T | — | uncertain significance |
| rs752139238 | 2:152,132,354 | C/T | — | uncertain significance |
| rs2467676007 | 2:152,132,359 | G/T | — | likely benign |
| rs1167096096 | 2:152,135,429 | T/C | — | uncertain significance |
| rs781138618 | 2:152,135,494 | T/C | — | uncertain significance |
| rs289828 | 2:152,137,181 | C/T | intron variant | — |
| rs2467684883 | 2:152,138,476 | T/C | — | uncertain significance |
| rs1406318181 | 2:152,138,538 | G/T | — | uncertain significance |
| rs11683487 | 2:152,142,549 | G/A | — | — |
| rs2194492 | 2:152,146,194 | G/C | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.